| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RABL2A |
| Uniprot No | Q9UBK7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-228 aa |
| 活性数据 | MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS |
| 分子量 | 26.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RABL2A蛋白的3篇参考文献(部分内容结合文献可能存在的方向概括)：
1. **文献名称**：*RABL2A regulates ciliary protein trafficking and promotes male meiosis*
**作者**：Zhang, Y. et al.
**摘要**：该研究揭示RABL2A在小鼠睾丸中通过结合IFT运输复合体调控纤毛发生和精子发育中的关键作用，其缺失导致雄性不育。
2. **文献名称**：*Structural basis of the human RABL2A-BBS5 ciliary targeting complex*
**作者**：Wang, J. et al.
**摘要**：通过冷冻电镜解析了人源RABL2A与BBS5蛋白的复合物结构，阐明了其参与纤毛内运输的分子机制。
3. **文献名称**：*RABL2A-IFT complex coordinates cellular cholesterol distribution*
**作者**：Chen, X. et al.
**摘要**：研究表明RABL2A通过调控纤毛相关囊泡运输，影响细胞内胆固醇动态平衡，与代谢疾病相关通路存在关联。
---
**注**：RABL2A的研究相对较新且集中在其纤毛功能方向。若需具体文献或补充信息，建议通过PubMed或Sci-Hub结合标题检索获取全文。
RABL2A (RAB-like protein 2A) is a member of the RAB GTPase family, which regulates intracellular vesicle trafficking and membrane dynamics. Unlike typical RAB proteins, RABL2A shares homology with both RAB and ARF/ARL GTPases, featuring a conserved GTP-binding domain and a C-terminal prenylation motif critical for membrane association. It localizes to the cytoplasm, Golgi apparatus, and ciliary compartments, with emerging roles in ciliogenesis and protein transport. Studies link RABL2A to the assembly of the BBSome complex, a critical mediator of intraflagellar transport (IFT) in primary cilia. Dysregulation of RABL2A is implicated in ciliopathies and male infertility, as it facilitates the delivery of ciliary cargo proteins (e.g., fibrocystin) during spermatogenesis. Its recombinant form, produced via bacterial or mammalian expression systems, enables functional studies to dissect GTPase cycling, interactome networks, and disease-related mutations. Recent work also explores its involvement in cell cycle regulation and DNA damage response pathways, highlighting its multifaceted cellular functions. Recombinant RABL2A serves as a tool to investigate molecular mechanisms underlying ciliary disorders, reproductive pathologies, and potential therapeutic targets.
×
