关键信息
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基因名
C9orf95
- 应用
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别名
C9orf95; Nicotinamide riboside kinase 1; Nicotinic acid riboside kinase 1; Nik-related Protein kinase; NRK 1; NRK; NRK_HUMAN; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z2Y5
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表达区间
1-199aa
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氨基酸序列
MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQDITWEVVYLDGTKSEEDLFLQVYEDLIQELAKQKCLQVTA
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分子量
49.6 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
C9orf95, a gene located on chromosome 9, has gained significant attention in recent years due to its potential involvement in various neurological disorders, particularly those associated with neurodegeneration. Research has shown that mutations in the C9orf72 gene, closely related to C9orf95, are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These conditions may arise from a pathological accumulation of dipeptide repeats produced by the expansion of a G4C2 repeat sequence. C9orf95, as a protein expressed in the central nervous system, is hypothesized to play a crucial role in cellular mechanisms and neuronal function. Studies have suggested that C9orf95 interacts with various signaling pathways, contributing to neuromodulation and synaptic plasticity. The recombinant expression of C9orf95 provides a valuable tool for probing its function and understanding the molecular underpinnings of associated diseases. Analyzing the structural and functional properties of this protein can offer insights into its potential as a therapeutic target in neurodegenerative disorders. New strategies utilizing C9orf95 and its pathways may pave the way for novel intervention approaches, underscoring the importance of continued research in this rapidly evolving field.
