| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RRP22 |
| Uniprot No | Q92737 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-200 aa |
| 活性数据 | MGGSLRVAVL GAPGVGKTAI IRQFLFGDYP ERHRPTDGPR LYRPAVLLDG AVYDLSIRDG DVAGPGSSPG GPEEWPDAKD WSLQDTDAFV LVYDICSPDS FDYVKALRQR IAETRPAGAP EAPILVVGNK RDRQRLRFGP RRALAALVRR GWRCGYLECS AKYNWHVLRL FRELLRCALV RARPAHPALR LQGALHPARC |
| 分子量 | 22.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RRP22蛋白的3-4条假设性参考文献的示例(请注意，这些文献信息为示例，实际引用需检索数据库核实)：
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1. **文献名称**: *"The role of RRP22 in tumor suppression through regulation of cell migration in colorectal cancer"*
**作者**: Kudo, Y., et al.
**摘要**: 研究揭示了RRP22作为肿瘤抑制因子在结直肠癌中的作用，发现其低表达与癌细胞迁移能力增强相关，可能通过调控Ras/MAPK信号通路抑制肿瘤进展。
2. **文献名称**: *"RRP22 modulates MMP2 expression to suppress glioblastoma cell invasion"*
**作者**: Liu, H., et al.
**摘要**: 本文报道了RRP22在神经胶质瘤中通过下调基质金属蛋白酶MMP2的活性，抑制肿瘤细胞侵袭和转移的分子机制。
3. **文献名称**: *"RNA-binding protein RRP22 regulates gene expression and apoptosis via alternative splicing"*
**作者**: Smith, J., et al.
**摘要**: 探索了RRP22作为RNA结合蛋白在RNA代谢中的作用，证明其通过介导特定mRNA的剪接调控基因表达，并影响细胞凋亡过程。
4. **文献名称**: *"Epigenetic silencing of RRP22 correlates with poor prognosis in esophageal squamous cell carcinoma"*
**作者**: Chen, L., et al.
**摘要**: 分析了食管鳞癌中RRP22启动子区高甲基化导致的表达缺失，其沉默与患者预后不良相关，提示其作为临床标志物的潜力。
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**注意**：以上文献内容为示例性概括，实际研究中请通过 **PubMed** 或 **Web of Science** 等平台检索关键词(如“RRP22”、“tumor suppression”或“RNA-binding protein”)获取真实文献。建议结合最新研究以涵盖该蛋白在癌症、RNA代谢等领域的最新进展。
Recombinant human RRP22 (Ras-related protein on chromosome 22), also known as RBSP3 or C9orf82. is a poorly characterized protein encoded by the RRP22 gene located on chromosome 9p21.3. It belongs to the Ras superfamily of small GTPases, which are critical molecular switches regulating diverse cellular processes such as signal transduction, cytoskeleton organization, and vesicle trafficking. Structurally, RRP22 contains a conserved GTP-binding domain and a C-terminal cysteine-rich region, but its exact molecular functions remain elusive.
Emerging studies suggest RRP22 may act as a tumor suppressor, particularly in colorectal cancer, where its expression is frequently downregulated due to promoter hypermethylation. Loss of RRP22 correlates with advanced tumor stages and poor prognosis. Mechanistically, it appears to interact with p53 signaling pathways, potentially enhancing p53-mediated apoptosis and suppressing cell proliferation. Interestingly, RRP22 shows nucleolar localization and may participate in RNA metabolism or ribosome biogenesis, though detailed mechanisms require further validation.
Its recombinant form enables functional studies in cancer biology, providing tools to explore its role in oncogenesis and therapeutic potential. However, conflicting reports about its subcellular distribution and tissue-specific expression patterns highlight the need for more comprehensive characterization. Current research focuses on deciphering its interaction networks and regulatory roles in both normal physiology and disease contexts.
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