| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SNX22 |
| Uniprot No | Q96L94 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-193 aa |
| 活性数据 | MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL HKRIKKLYKV PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE LLEFLRLRHF PTDPKASNWG TLREFLPGDS SSQQHQRPVL SFHVDPYVCN PSPESLPNVV VNGVLQGLYS FSISPDKAQP KAACHPAPLP PMP |
| 分子量 | 22.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SNX22蛋白的假设性参考文献示例(注：SNX22相关研究较少，以下内容为模拟虚构，仅供参考)：
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1. **文献名称**: *Expression and functional characterization of recombinant human SNX22 in endosomal trafficking*
**作者**: Smith A, et al.
**摘要**: 本研究成功在大肠杆菌中表达了重组人SNX22蛋白，并通过体外实验证明其通过PX结构域与特定磷脂酰肌醇结合，参与早期内体膜运输过程。
2. **文献名称**: *Structural insights into the PX domain of SNX22 and its role in autophagy regulation*
**作者**: Zhang L, et al.
**摘要**: 通过晶体学解析SNX22的PX结构域三维结构，发现其与自噬相关蛋白LC3的相互作用机制，重组SNX22在细胞实验中显示出调控自噬体形成的功能。
3. **文献名称**: *SNX22 deficiency alters lysosomal degradation pathways: Evidence from recombinant protein rescue models*
**作者**: Johnson R, et al.
**摘要**: 利用重组SNX22蛋白在基因敲除细胞系中进行功能补偿实验，证实SNX22缺失导致溶酶体酶运输异常，暗示其在神经退行性疾病中的潜在作用。
4. **文献名称**: *High-yield purification of recombinant human SNX22 and its lipid-binding specificity analysis*
**作者**: Tanaka K, et al.
**摘要**: 开发了一种昆虫细胞表达系统高效纯化重组SNX22的方法，并利用脂质体结合实验证明其对PI(3)P的特异性识别能力。
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**注意**：SNX22的研究文献有限，上述内容为示例性虚构，实际研究中建议通过PubMed或Web of Science以“SNX22”或“Sorting Nexin 22”为关键词检索最新成果，并核实具体信息。
**Background of Recombinant Human SNX22 Protein**
Sorting nexin 22 (SNX22) is a member of the sorting nexin (SNX) family, which plays critical roles in membrane trafficking, protein sorting, and cellular signaling. SNX proteins are characterized by the presence of a Phox homology (PX) domain, enabling interaction with phosphatidylinositol phospholipids on membranes. SNX22. specifically, is implicated in regulating endosomal dynamics, intracellular transport, and receptor recycling, though its precise biological functions remain less defined compared to other SNXs like SNX1 or SNX3.
As a recombinant protein, human SNX22 is produced via molecular cloning and expression in heterologous systems (e.g., *E. coli* or mammalian cells), allowing high-purity isolation for functional studies. Its recombinant form enables researchers to explore its interactions with partner proteins, lipid-binding specificity, and role in cellular pathways such as endocytosis, autophagy, or vesicle formation. SNX22 has also been linked to disease contexts, including cancer and neurological disorders, where aberrant membrane trafficking contributes to pathogenesis.
Ongoing research focuses on elucidating SNX22's structural motifs beyond the PX domain, its regulatory mechanisms, and its potential as a therapeutic target. The availability of recombinant SNX22 accelerates biochemical assays, structural studies, and drug discovery efforts, enhancing our understanding of its contributions to cellular homeostasis and disease.
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