| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SNX6 |
| Uniprot No | Q9UNH7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-406 aa |
| 活性数据 | MMEGLDDGPD FLSEEDRGLK AINVDLQSDA ALQVDISDAL SERDKVKFTV HTKSSLPNFK QNEFSVVRQH EEFIWLHDSF VENEDYAGYI IPPAPPRPDF DASREKLQKL GEGEGSMTKE EFTKMKQELE AEYLAIFKKT VAMHEVFLCR VAAHPILRRD LNFHVFLEYN QDLSVRGKNK KEKLEDFFKN MVKSADGVIV SGVKDVDDFF EHERTFLLEY HNRVKDASAK SDRMTRSHKS AADDYNRIGS SLYALGTQDS TDICKFFLKV SELFDKTRKI EARVSADEDL KLSDLLKYYL RESQAAKDLL YRRSRSLVDY ENANKALDKA RAKNKDVLQA ETSQQLCCQK FEKISESAKQ ELIDFKTRRV AAFRKNLVEL AELELKHAKG NLQLLQNCLA VLNGDT |
| 分子量 | 46.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SNX6蛋白的3篇示例参考文献(内容为示例性质，非真实文献)：
---
1. **"Purification and functional characterization of recombinant human SNX6"**
*Kurten, R.C. et al. (2012), Biochemical Journal*
摘要：研究报道了通过大肠杆菌系统表达并纯化重组人SNX6蛋白，证实其通过PX结构域与细胞内膜结构相互作用，参与内吞体分选过程。
2. **"SNX6 regulates retrograde transport of IGF2R by interacting with retromer complex"**
*Zhong, Q. et al. (2015), Journal of Biological Chemistry*
摘要：研究发现重组SNX6蛋白与Retromer复合体形成相互作用，调控胰岛素样生长因子受体(IGF2R)的逆向运输功能，揭示了其在细胞信号转导中的作用。
3. **"A novel role of SNX6 in modulating EGFR degradation and cancer progression"**
*Teuchert, M. et al. (2018), Cellular Signalling*
摘要：通过重组SNX6蛋白的功能实验，证明其通过影响表皮生长因子受体(EGFR)的内吞降解通路，调控肿瘤细胞的迁移与侵袭。
---
⚠️ 以上为模拟参考文献，真实文献建议通过 **PubMed/Google Scholar** 以关键词 **"SNX6 recombinant protein"、"Sorting Nexin 6 function"** 检索获取。
**Background of Recombinant Human SNX6 Protein**
Sorting nexin 6 (SNX6) is a member of the sorting nexin family, which plays critical roles in membrane trafficking, endosomal sorting, and cellular signaling. SNX6 contains a phox homology (PX) domain that binds phosphatidylinositol lipids, directing its localization to endosomal membranes, and a coiled-coil domain facilitating interactions with other proteins. It often functions as part of the retromer complex or associates with SNX1/SNX2 to regulate cargo sorting, vesicle formation, and retrograde transport from endosomes to the Golgi apparatus.
SNX6 participates in diverse processes, including receptor recycling (e.g., EGFR), lysosomal degradation, and maintaining cellular homeostasis. Dysregulation of SNX6 has been linked to neurological disorders, cancer, and immune dysfunction, highlighting its importance in pathophysiology.
Recombinant human SNX6 protein, produced using expression systems like *E. coli* or mammalian cells, retains functional domains and post-translational modifications (if expressed in eukaryotic systems). It serves as a vital tool for studying SNX6-mediated trafficking mechanisms, protein interactions, and its role in disease models. Its applications span *in vitro* biochemical assays, structural studies, and drug discovery targeting endosomal pathways. The recombinant form enables precise analysis of SNX6’s molecular functions, aiding therapeutic development for related disorders.
×
