| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SNX7 |
| Uniprot No | Q9UNH6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-387 aa |
| 活性数据 | MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN DDFIETRRKA LHKFLNRIAD HPTLTFNEDF KIFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK NRPEEFMEMN NFIELFSQKI NLIDKISQRI YKEEREYFDE MKEYGPIHIL WSASEEDLVD TLKDVASCID RCCKATEKRM SGLSEALLPV VHEYVLYSEM LMGVMKRRDQ IQAELDSKVE VLTYKKADTD LLPEEIGKLE DKVECANNAL KADWERWKQN MQNDIKLAFT DMAEENIHYY EQCLATWESF LTSQTNLHLE EASEDKP |
| 分子量 | 45.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SNX7蛋白的3条示例参考文献(基于文献常见研究方向虚构示例，非真实存在)：
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1. **标题**：*Structural Insights into the SNX7 Protein and Its Role in Endosomal Sorting*
**作者**：Zhang L, et al.
**摘要**：本研究解析了重组人SNX7蛋白的晶体结构，揭示了其PHOX结构域与磷脂酰肌醇结合的关键位点，并证明SNX7在核内体膜重塑和货物蛋白分选中起重要作用。
2. **标题**：*SNX7 Regulates Autophagosome-Lysosome Fusion through Interaction with ATG14L*
**作者**：Wang Y, et al.
**摘要**：通过体外重组SNX7蛋白实验，作者发现SNX7通过结合自噬相关蛋白ATG14L，调控自噬体-溶酶体融合过程，为自噬功能障碍相关疾病提供新机制解释。
3. **标题**：*Recombinant SNX7 Expression Enhances Wnt Signaling in Colorectal Cancer Cells*
**作者**：Chen R, et al.
**摘要**：研究在大肠癌细胞中过表达重组SNX7蛋白，发现其通过稳定β-catenin蛋白增强Wnt信号通路活性，促进肿瘤细胞侵袭，提示SNX7可作为潜在治疗靶点。
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注：以上为模拟文献示例，实际研究中请通过PubMed或Web of Science检索真实文献。
Sorting nexin 7 (SNX7) is a member of the sorting nexin family, a group of cytoplasmic and membrane-associated proteins involved in intracellular trafficking, membrane remodeling, and protein sorting. Like other sorting nexins, SNX7 contains a conserved phox homology (PX) domain that binds phosphatidylinositol phosphates, enabling its recruitment to specific membrane compartments, such as endosomes. SNX7 lacks the BAR domain found in some nexins but may interact with BAR-containing proteins to regulate membrane curvature and vesicle formation. It forms homodimers or heterodimers with other SNXs (e.g., SNX1 or SNX2), contributing to endosomal cargo sorting, retrograde transport to the Golgi, or lysosomal degradation pathways.
SNX7 has been implicated in multiple cellular processes, including receptor recycling (e.g., EGFR), autophagy, and maintaining endosome-lysosome system integrity. Studies suggest its role in modulating Wnt/β-catenin signaling and cell proliferation, with potential links to cancer progression. While less characterized than other SNXs, SNX7 is expressed ubiquitously, and its dysregulation has been associated with neurodegenerative diseases and metabolic disorders. Recombinant human SNX7 protein is widely used in biochemical assays (e.g., protein-protein interaction studies) and cell-based experiments to explore its molecular mechanisms and therapeutic relevance. Further research is needed to clarify its precise physiological roles and disease connections.
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