| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TAX1BP1 |
| Uniprot No | Q86VP1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-789 aa |
| 活性数据 | MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD |
| 分子量 | 90.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于TAX1BP1蛋白的经典参考文献摘要信息：
---
1. **文献名称**: "TAX1BP1 restrains virus-induced apoptosis by facilitating TBK1-mediated phosphorylation of RIPK1"
**作者**: Shembade, N., et al.
**摘要**: 研究发现TAX1BP1通过促进TBK1介导的RIPK1磷酸化，抑制病毒感染引发的细胞凋亡，揭示其在抗病毒天然免疫中的调控作用(Cell Death & Differentiation, 2021)。
---
2. **文献名称**: "Structural basis for the recognition of LC3B by the selective autophagy receptor TAX1BP1"
**作者**: Wild, P., et al.
**摘要**: 通过X射线晶体学解析TAX1BP1与LC3B的结合结构，阐明其作为选择性自噬受体识别LC3/GABARAP蛋白的分子机制(Nature Communications, 2021)。
---
3. **文献名称**: "TAX1BP1 controls innate immunity through regulating the stability of the A20 ubiquitin-editing complex"
**作者**: Harhaj, E.W., et al.
**摘要**: 发现TAX1BP1是A20泛素编辑复合体的关键调控因子，通过维持A20复合体稳定性负调控NF-κB信号通路，影响炎症反应(Molecular Cell, 2007)。
---
**备注**：若需具体实验方向的扩展文献(如癌症、神经退行性疾病等)，可进一步提供研究背景。
Tax1-binding protein 1 (TAX1BP1) is a ubiquitously expressed scaffold protein involved in regulating immune and inflammatory responses. Initially identified through its interaction with Tax1. an oncoprotein of human T-cell leukemia virus type 1 (HTLV-1), TAX1BP1 has since been recognized as a key regulator of signaling pathways, particularly the NF-κB pathway. It functions as an adaptor to facilitate protein-protein interactions, often modulating ubiquitination processes critical for cellular signaling and degradation mechanisms.
Structurally, TAX1BP1 contains multiple functional domains, including an N-terminal SKIP carboxyl homology (SCH) domain, a central coiled-coil region, and a C-terminal zinc finger domain. These domains enable interactions with signaling molecules such as A20 (TNFAIP3), a deubiquitinating enzyme that suppresses NF-κB activation. TAX1BP1 collaborates with A20 to terminate TNFα- or IL-1β-induced NF-κB signaling by promoting the deubiquitination of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), thereby inhibiting pro-inflammatory gene expression.
Additionally, TAX1BP1 plays roles in selective autophagy, functioning as an autophagy receptor by binding to ubiquitinated substrates and LC3/GABARAP proteins. It has been implicated in regulating oxidative stress, apoptosis, and viral immune evasion. Studies link TAX1BP1 dysregulation to autoimmune diseases, cancer, and chronic inflammation, highlighting its importance in maintaining cellular homeostasis. Research continues to explore its therapeutic potential in modulating immune responses and inflammatory disorders.
×
