| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF167 |
| Uniprot No | Q9P0L1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-754 aa |
| 活性数据 | MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA WSVS |
| 分子量 | 85.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF167蛋白的示例参考文献(文献为虚拟示例，实际文献请查阅数据库确认)：
1. **文献名称**：*"ZNF167 regulates neuronal differentiation through chromatin remodeling"*
**作者**：Zhang L, et al.
**摘要**：研究通过体外重组表达人ZNF167蛋白，发现其通过结合特定DNA序列调控神经元分化相关基因的染色质结构，提示其在神经发育中的潜在作用。
2. **文献名称**：*"Structural and functional analysis of recombinant human ZNF167 in cancer cell proliferation"*
**作者**：Wang Y, et al.
**摘要**：报道了重组ZNF167蛋白的晶体结构解析，并在乳腺癌细胞模型中验证了其通过抑制细胞周期蛋白表达，调控肿瘤细胞增殖的功能。
3. **文献名称**：*"ZNF167 interacts with HDAC1 to modulate gene silencing in stem cells"*
**作者**：Kim S, et al.
**摘要**：利用重组ZNF167蛋白进行免疫共沉淀实验，发现其与组蛋白去乙酰化酶HDAC1相互作用，参与维持干细胞多能性相关基因的表观遗传沉默。
4. **文献名称**：*"High-throughput screening of ZNF167-binding motifs using recombinant protein libraries"*
**作者**：Müller F, et al.
**摘要**：通过重组ZNF167蛋白库及高通量DNA结合实验，鉴定了其偏好结合的DNA基序，并预测了其在基因组中可能调控的靶基因网络。
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注：以上为模拟生成的参考文献，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。如需进一步指导，请提供更多具体研究方向!
Zinc finger protein 167 (ZNF167), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, plays a role in transcriptional regulation and cellular processes. Located on human chromosome 7q22.1. it encodes a protein characterized by multiple C2H2-type zinc finger motifs, which enable sequence-specific DNA binding. The KRAB domain, a hallmark of this protein subgroup, is implicated in recruiting transcriptional co-repressors to regulate gene expression. ZNF167 also contains a SCAN domain, mediating selective protein-protein interactions. While its precise biological functions remain under investigation, studies suggest involvement in cell proliferation, differentiation, or apoptosis modulation.
The recombinant human ZNF167 protein, typically produced in *E. coli* or mammalian expression systems, retains these functional domains for experimental studies. Researchers employ it to elucidate DNA-binding specificity, protein interaction networks, and regulatory mechanisms in both normal and pathological contexts. Emerging evidence links ZNF167 dysregulation to certain cancers, with altered expression observed in tumor tissues, though its oncogenic or tumor-suppressive role requires further validation. Its recombinant form facilitates structural studies, antibody development, and high-throughput screening for potential therapeutic targeting. Current research focuses on mapping its target genes and clarifying its contribution to cellular pathways and disease progression.
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