关键信息
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基因名
FOLR1
- 应用
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别名
FOLR1；FOLR；Folate receptor alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15328
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表达区间
25-233aa
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氨基酸序列
RIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAM
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分子量
25.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
FOLR1, or folate receptor 1, is a membrane-bound glycoprotein that plays a crucial role in cellular folate uptake, which is vital for DNA synthesis, repair, and methylation processes. Its expression is particularly upregulated in several types of cancer, making it a significant biomarker and therapeutic target. Research into FOLR1 has gained momentum due to its potential applications in targeted drug delivery and cancer immunotherapy. The overexpression of FOLR1 in tumor tissues, while being low in normal adult tissues, presents opportunities for developing FOLR1-targeted therapies that can specifically target cancer cells while sparing healthy cells. This specificity is essential for minimizing side effects commonly associated with traditional chemotherapeutics. Recent advancements in recombinant protein technology allow for the production of FOLR1 and its derivatives, paving the way for novel diagnostic tools, such as imaging agents and antibody-drug conjugates. Investigating the structure and function of FOLR1 not only aids in understanding its role in cancer biology but also enhances the development of innovative treatments. As researchers continue to explore the therapeutic potential of FOLR1, its role in promoting tumor progression and influencing the tumor microenvironment remains an active area of study, offering promise for improved cancer management strategies.
