| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF37A |
| Uniprot No | P17032 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-561 aa |
| 活性数据 | MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC IPKPEVILKL EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG KCFCDEKHEI IHSEEEPSEY NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE CGKAFPENSL FLVHKRGYTG QKTCKYTEHG KTCDMSFFIT HQQTHPRENH YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN NIIEYNECGT FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT GEKPYECHEC GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK HQRIHTGEKP YECNECGKSF SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS ALIVHQRTHI RQKPYGCNQC GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV HQRIHLGRNP INVVNEGNYS G |
| 分子量 | 65.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF37A蛋白的假设性参考文献示例(注：因ZNF37A相关研究较少，以下内容为模拟示例，非真实文献)：
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1. **文献名称**: "Cloning and Functional Characterization of Recombinant Human ZNF37A Protein"
**作者**: Smith J, et al.
**摘要**: 本研究报道了人ZNF37A基因的克隆及其在大肠杆菌中的重组表达。通过亲和层析纯化获得高纯度蛋白，并证实其具有DNA结合活性，暗示其在转录调控中的潜在作用。
2. **文献名称**: "Structural Analysis of ZNF37A Zinc Finger Domain Using X-ray Crystallography"
**作者**: Lee H, et al.
**摘要**: 通过X射线晶体学解析了ZNF37A锌指结构域的三维结构，揭示了其特异性识别DNA基序的分子机制，为设计靶向该蛋白的抑制剂提供结构基础。
3. **文献名称**: "ZNF37A Modulates Oncogenic Pathways in Breast Cancer Cells"
**作者**: Garcia R, et al.
**摘要**: 利用重组ZNF37A蛋白进行体外功能实验，发现其过表达抑制乳腺癌细胞增殖，可能通过调控Wnt/β-catenin信号通路发挥作用。
4. **文献名称**: "A High-Throughput Screen for ZNF37A Interaction Partners"
**作者**: Wang Y, et al.
**摘要**: 采用重组ZNF37A蛋白进行蛋白质互作组学分析，鉴定出多个新型结合蛋白，提示其在染色质重塑复合物中的潜在功能。
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**注意事项**：
- ZNF37A在真实文献中研究较少，以上内容仅为模拟参考。
- 建议通过PubMed、Web of Science等数据库，结合关键词“ZNF37A”或“Zinc Finger Protein 37A”检索最新研究。
Recombinant human ZNF37A protein is a genetically engineered form of the zinc finger protein 37A (ZNF37A), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZFP) family. Zinc finger proteins are characterized by tandem arrays of zinc finger motifs, which mediate sequence-specific DNA binding, enabling their role in transcriptional regulation. ZNF37A, located on human chromosome 10. contains multiple C2H2-type zinc finger domains and a KRAB domain, which typically recruits co-repressors to regulate gene expression through chromatin remodeling. Although the precise biological functions of ZNF37A remain understudied, it is hypothesized to participate in developmental processes, cell differentiation, and tumor suppression, akin to related KRAB-ZFPs. Dysregulation of zinc finger proteins has been linked to cancers and genetic disorders, making ZNF37A a potential target for biomedical research. Recombinant ZNF37A is produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies, enabling investigations into its DNA-binding specificity, interaction partners, and regulatory mechanisms. Its recombinant form allows standardized analysis of its structure-function relationships and therapeutic potential, particularly in gene editing or synthetic biology applications leveraging zinc finger domains for targeted DNA recognition. Further research is needed to elucidate its physiological roles and disease relevance.
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