| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SYNC |
| Uniprot No | Q9H7C4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-482aa |
| 氨基酸序列 | MASPEPRRGG DGAAQAARKT RVEANSPLPK NSGSLNEAEA LNPEVTLSSE GSLNLEDILY LEDTGDLDET LYVQETEKAE EALYIEEAMQ PDEALHVEEP GNPEETVCVE ETTEPDRIQF VEGPVEPGKP TSPEHVVYEG ETVTRAEKSN PEESLRAEQS PSMEENLSIE DLELLEGRFQ QCVQAVAQLE EERDQLIHEL VLLREPALQE VQQVHQDILA AYKLHAQAEL ERDGLREEIR LVKQKLFKVT KECVAYQYQL ECRQQDVAQF ADFREVLTTR ATQLSEELAQ LRDAYQKQKE QLRQQLEAPP SQRDGHFLQE SRRLSAQFEN LMAESRQDLE EEYEPQFLRL LERKEAGTKA LQRTQAEIQE MKEALRPLQA EARQLRLQNR NLEDQIALVR QKRDEEVQQY REQLEEMEER QRQLRNGVQL QQQKNKEMEQ LRLSLAEELS TYKAMLLPKS LEQADAPTSQ AGGMETQSQG AV |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SYNC重组蛋白的假设性参考文献示例(注：SYNC蛋白相关研究较少，以下内容为模拟，非真实文献)：
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1. **文献名称**：*Structural and Functional Analysis of SYNC Recombinant Protein in Cell Cycle Regulation*
**作者**：Smith, J. et al.
**摘要**：本研究通过原核表达系统成功制备了SYNC重组蛋白，并解析了其晶体结构。实验表明，SYNC通过与细胞周期蛋白Cyclin D1相互作用，调控G1/S期转换，为癌症治疗提供了潜在靶点。
2. **文献名称**：*SYNC Recombinant Protein Enhances Synaptic Plasticity in Neuronal Models*
**作者**：Zhang, L. & Wang, H.
**摘要**：利用哺乳动物细胞表达纯化的SYNC重组蛋白，发现其能够促进海马神经元突触可塑性，通过激活MAPK信号通路改善记忆损伤模型小鼠的认知功能。
3. **文献名称**：*Application of SYNC Recombinant Protein in Viral Infection Inhibition*
**作者**：Kim, S. et al.
**摘要**：研究发现，SYNC重组蛋白通过结合流感病毒血凝素(HA)蛋白，阻断病毒与宿主细胞膜融合，在体外实验中显示出显著的抗病毒活性。
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如需真实文献，建议通过学术数据库(如PubMed、Web of Science)以“SYNC protein”或“SYNC recombinant”为关键词检索，并核实具体研究背景。
SYNC recombinant proteins, often derived from syncytin proteins, are engineered molecules inspired by endogenous retroviral envelope glycoproteins co-opted during mammalian evolution. Syncytins, such as syncytin-1 (encoded by the HERV-W gene) and syncytin-2 (from HERV-FRD), play critical roles in placental development by mediating cell-cell fusion to form syncytiotrophoblasts, essential for maternal-fetal nutrient exchange and immune tolerance. These proteins exhibit a characteristic structure: a surface (SU) subunit for receptor binding and a transmembrane (TM) subunit enabling membrane fusion via hydrophobic domains.
Recombinant SYNC proteins are produced using expression systems (e.g., mammalian, insect, or bacterial cells) to study their fusogenic mechanisms or repurpose their fusion capabilities for biomedical applications. Their ability to merge cell membranes has sparked interest in drug delivery systems, gene therapy vectors, and cancer immunotherapy tools. For instance, engineered SYNC proteins could enhance targeted delivery of therapeutics by fusing carrier vesicles with specific cell types.
Research also explores their dual role in health and disease. While vital for placental development, aberrant syncytin expression is linked to pathologies like preeclampsia, multiple sclerosis, and certain cancers. Recombinant variants allow precise investigation of these mechanisms, aiding therapeutic development. Challenges include optimizing protein stability, minimizing immunogenicity, and ensuring tissue-specific targeting. Current studies focus on structural modifications to improve functionality while reducing off-target effects. As tools bridging virology and regenerative medicine, SYNC recombinant proteins represent a unique intersection of evolutionary biology and translational innovation.
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