| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TMEM2L |
| Uniprot No | P |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | aa |
| 氨基酸序列 | full |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TMEM2L重组蛋白的3篇参考文献(注：目前公开数据库中关于TMEM2L的研究较少，以下内容为模拟示例，实际文献可能需要进一步验证或补充)：
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1. **文献名称**：*TMEM2L重组蛋白在细胞迁移中的作用研究*
**作者**：Zhang Y, et al.
**摘要**：本研究成功表达并纯化了人源TMEM2L重组蛋白，发现其通过调控细胞外基质重塑促进癌细胞迁移，提示其在肿瘤转移中的潜在作用。
2. **文献名称**：*TMEM2L的结构与功能分析*
**作者**：Smith J, Lee K.
**摘要**：通过X射线晶体学解析TMEM2L重组蛋白的三维结构，揭示了其跨膜结构域特征，并发现其可能参与细胞膜相关信号通路。
3. **文献名称**：*TMEM2L重组蛋白的体外酶活性检测*
**作者**：Wang H, et al.
**摘要**：实验表明，TMEM2L重组蛋白具有透明质酸水解酶活性，可能类似TMEM2家族成员，在组织稳态中发挥作用。
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**备注**：目前关于TMEM2L的公开研究较少，上述内容基于类似蛋白(如TMEM2)的功能推测。建议结合跨膜蛋白(TMEM家族)或透明质酸代谢相关文献进行扩展检索。
**Background of TMEM2L Recombinant Protein**
TMEM2L (Transmembrane Protein 2-like) is a less-characterized member of the transmembrane protein family, hypothesized to share structural or functional similarities with TMEM2. a known hyaluronidase involved in extracellular matrix (ECM) remodeling. TMEM2. its putative homolog, plays a critical role in degrading hyaluronic acid (HA), a major glycosaminoglycan regulating tissue hydration, cell migration, and inflammation. While TMEM2L’s precise biological function remains unclear, its sequence homology suggests potential involvement in HA metabolism or ECM homeostasis.
Recombinant TMEM2L protein is typically produced using expression systems like mammalian cells or insect cells to ensure proper post-translational modifications. Its study aims to elucidate its enzymatic activity, substrate specificity, and interaction partners. Preliminary research links TMEM2 family proteins to developmental processes, tissue repair, and pathologies such as cancer and fibrosis. For instance, TMEM2-mediated HA degradation influences tumor microenvironment dynamics, suggesting TMEM2L might have analogous roles.
Current investigations focus on TMEM2L’s potential as a therapeutic target or biomarker. Its recombinant form enables *in vitro* assays to probe its biochemical properties and screen inhibitors/activators. Challenges include clarifying its distinction from TMEM2 and verifying tissue-specific expression patterns. Further studies are needed to define its physiological relevance, particularly in HA-rich contexts like cartilage, skin, or inflammatory sites.
In summary, TMEM2L recombinant protein serves as a tool to explore an understudied protein with implications in ECM biology and disease mechanisms, bridging gaps between structural homology and functional validation.
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