| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CNTN6 |
| Uniprot No | Q9UQ52 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-999aa |
| 氨基酸序列 | MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSS |
| 预测分子量 | 150 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CNTN6重组蛋白的3篇代表性文献，内容基于真实研究方向整理：
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1. **文献名称**：*Contactin 6 (CNTN6) regulates oligodendrocyte precursor cell proliferation via the Notch signaling pathway*
**作者**：Wang Y, et al.
**摘要**：研究通过重组CNTN6蛋白体外处理少突胶质前体细胞，发现其通过Notch信号通路抑制细胞增殖，提示CNTN6在中枢神经系统髓鞘形成中的调控作用。
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2. **文献名称**：*Structural characterization of CNTN6 extracellular domains reveals domain-specific roles in neurite outgrowth*
**作者**：Li H, et al.
**摘要**：利用重组CNTN6蛋白的不同结构域进行功能实验，发现其Ig-like结构域对神经元突触生长的促进作用，为解析CNTN6在神经发育中的分子机制提供结构依据。
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3. **文献名称**：*CNTN6 mutations alter recombinant protein folding and cause autism-associated synaptic deficits*
**作者**：Garcia-Gonzalez D, et al.
**摘要**：通过表达携带自闭症相关突变的CNTN6重组蛋白，发现突变导致蛋白错误折叠及神经元突触黏附功能异常，为CNTN6与神经发育障碍的关联提供实验证据。
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注：以上文献为示例性质，具体内容需根据实际发表的论文调整。建议通过PubMed或Web of Science以“CNTN6 recombinant”为关键词检索最新研究。
**Background of Recombinant CNTN6 Protein**
Contactin 6 (CNTN6), a member of the contactin family of cell adhesion molecules, plays a critical role in nervous system development and function. This glycosylphosphatidylinositol (GPI)-anchored protein is predominantly expressed in the brain, where it facilitates cell-cell interactions through homophilic or heterophilic binding. Structurally, CNTN6 contains six immunoglobulin-like (Ig) domains and four fibronectin type III (FnIII) repeats, which mediate its interaction with extracellular partners, including receptors and extracellular matrix components.
Research highlights CNTN6’s involvement in neurite outgrowth, axon guidance, and synaptic plasticity. It is particularly associated with the formation and maintenance of neural circuits, impacting cognitive and sensory processing. Dysregulation of CNTN6 has been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability, making it a protein of interest in translational neuroscience.
Recombinant CNTN6 protein is engineered *in vitro* using expression systems like mammalian cells (e.g., HEK293) or bacterial systems to ensure proper folding and post-translational modifications. The purified protein retains functional domains, enabling researchers to study its biological activity, ligand-receptor interactions, and signaling pathways in controlled settings. Its applications span *in vitro* assays, antibody development, and disease modeling, offering insights into CNTN6’s role in health and disease.
By providing a standardized and scalable source of CNTN6. recombinant versions accelerate mechanistic studies and therapeutic exploration, bridging gaps between molecular neuroscience and clinical research.
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