关键信息
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基因名
RIB/ALK-4
- 应用
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别名
6820432J04 Protein; ActR-IB Protein; ActRIB; Acvr1b Protein; Acvrlk4 Protein; ALK-4 Protein; Alk4 Protein; SKR2 Protein
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
NP_031421.1
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表达区间
M1-E126
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氨基酸序列
MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLDGVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPAHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RIB/ALK-4, also known as Activin receptor-like kinase 4, is a member of the TGF-β superfamily of receptors and plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, and the regulation of cell differentiation. The interest in RIB/ALK-4 has grown significantly due to its involvement in signaling pathways that influence the development of diseases such as cancer and fibrosis. This receptor primarily mediates the effects of Activin and Bone Morphogenetic Proteins (BMPs), which are vital for regulating cellular functions. Research into RIB/ALK-4 has revealed that its dysregulation can lead to abnormal cellular responses, contributing to pathological conditions. Studies have demonstrated that RIB/ALK-4 signaling is instrumental in the progression of certain tumors, making it a potential therapeutic target. Furthermore, understanding the molecular mechanisms by which RIB/ALK-4 interacts with other signaling pathways can provide insights into novel treatment strategies. The development of recombinant RIB/ALK-4 proteins offers valuable tools for investigating its functions, exploring receptor-ligand interactions, and screening for small molecules that can modulate its activity. Overall, research on RIB/ALK-4 not only enhances our understanding of fundamental biological processes but also opens avenues for targeted therapies in various diseases characterized by aberrant signaling pathways.
