| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZNF512 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ZNF512抗体的3篇假设性参考文献示例，基于常见研究场景构建：
---
1. **文献名称**：*ZNF512 suppresses hepatocellular carcinoma progression by modulating p53 signaling*
**作者**：Chen L, et al.
**摘要**：本研究通过免疫组化(使用ZNF512特异性抗体)发现，ZNF512在肝癌组织中表达显著下调，且低表达与患者不良预后相关。体外实验表明，ZNF512过表达可激活p53通路并抑制肿瘤细胞增殖，提示其作为抑癌基因的潜在作用。
2. **文献名称**：*ZNF512 regulates neuroinflammatory responses in microglia via NF-κB pathway*
**作者**：Wang Y, et al.
**摘要**：利用ZNF512抗体进行Western blot和免疫荧光染色，研究者发现ZNF512在小胶质细胞中高表达。敲除ZNF512后，LPS诱导的NF-κB活化和炎症因子(如IL-6、TNF-α)分泌显著增强，表明ZNF512通过抑制NF-κB通路负调控神经炎症。
3. **文献名称**：*Interaction between ZNF512 and HDAC1 promotes cell cycle arrest in gastric cancer*
**作者**：Zhang H, et al.
**摘要**：通过免疫共沉淀(使用ZNF512抗体)和质谱分析，本研究证实ZNF512与组蛋白去乙酰化酶HDAC1直接结合。该相互作用诱导细胞周期相关基因(如p21)的表观遗传修饰，导致胃癌细胞G1期阻滞，为ZNF512的抑癌机制提供了新见解。
---
**说明**：以上文献为假设性示例，实际研究中请通过PubMed、Web of Science等数据库检索具体文献。建议使用关键词“ZNF512 antibody”、“ZNF512 function”或结合研究领域(如“cancer”、“inflammation”)进行精准查询。
The ZNF512 antibody is a crucial tool for studying the zinc finger protein 512 (ZNF512), a member of the zinc finger protein family implicated in transcriptional regulation and cellular stress responses. ZNF512. also known as HIVEP3. contains multiple C2H2-type zinc finger domains, which enable its interaction with DNA or RNA to modulate gene expression. Research suggests ZNF512 plays roles in diverse biological processes, including cell proliferation, differentiation, and apoptosis. It has been linked to cancer progression (e.g., glioma, gastric cancer) and neurodegenerative diseases, potentially acting as a tumor suppressor or oncogene depending on context.
Studies highlight its involvement in oxidative stress pathways, where ZNF512 may regulate antioxidant enzymes like SOD2. offering protection against cellular damage. The ZNF512 antibody is widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, localization, and interactions in tissues or cell lines. Its specificity and validation (e.g., knockout validation) are critical for ensuring reliable results in both basic research and clinical studies.
As dysregulation of ZNF512 is increasingly associated with disease mechanisms, this antibody serves as a vital reagent for unraveling its molecular functions and therapeutic potential. Ongoing research aims to clarify its signaling networks and explore its utility as a biomarker or therapeutic target in precision medicine.
×
