| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ARH3; ADPRHL2; CONDSIAS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADPRS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADPRS(ADP-ribosylation)相关抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *Autoantibodies to Poly(ADP-Ribose) Polymerase in Autoimmune Diseases*
**作者**: Decker P, et al.
**摘要**: 该研究检测了系统性红斑狼疮(SLE)和类风湿关节炎(RA)患者血清中的抗PARP(ADP核糖聚合酶)抗体，发现其与疾病活动性及DNA损伤修复异常相关，提示其在自身免疫病理中的作用。
2. **文献名称**: *ADP-ribosylation in Immunity and Host-Pathogen Interactions*
**作者**: Lüscher B, et al.
**摘要**: 探讨ADP核糖基化在免疫调控中的机制，包括病原体感染后宿主细胞通过ADPRS抗体识别异常修饰蛋白，激活炎症信号通路，为感染与自身免疫交叉反应提供证据。
3. **文献名称**: *Anti-ADP-ribose Antibodies in Systemic Lupus Erythematosus*
**作者**: Yoshida K, et al.
**摘要**: 研究发现SLE患者中抗ADP核糖抗体水平显著升高，与抗dsDNA抗体和肾脏损伤呈正相关，提示其可作为SLE诊断及病情监测的生物标志物。
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**备注**：ADPRS相关研究多集中于ADP核糖基化修饰(如PARP家族)及其抗体在疾病中的作用。若需更具体的研究方向，建议补充关键词或研究背景。
**Background of ADPRS Antibodies**
ADP-ribosyl sulfatase (ADPRS) is an enzyme involved in the hydrolysis of ADP-ribose derivatives, playing a critical role in regulating post-translational modifications (PTMs) linked to cellular signaling, DNA repair, and epigenetic regulation. ADP-ribosylation, a reversible PTM mediated by poly(ADP-ribose) polymerases (PARPs) and removed by hydrolases like ADPRS, influences processes such as genomic stability, apoptosis, and inflammation. Dysregulation of ADP-ribose metabolism is implicated in cancer, neurodegenerative disorders, and autoimmune diseases.
ADPRS antibodies are essential tools for studying the expression, localization, and function of ADPRS in biological systems. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding research into ADPRS's interaction networks and regulatory mechanisms. Recent studies highlight ADPRS's potential role in mitigating oxidative stress and modulating PARP1 activity, linking it to therapeutic strategies for diseases involving DNA damage and PARP inhibitor resistance.
The development of specific ADPRS antibodies has advanced mechanistic insights into ADP-ribose homeostasis, offering avenues for biomarker discovery and targeted therapies. However, challenges remain in characterizing isoform-specific functions and substrate preferences. Ongoing research leverages these antibodies to unravel ADPRS's contributions to cellular resilience and pathology, positioning it as a promising focus in precision medicine and molecular diagnostics.
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