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Rabbit Polyclonal AMZ1 Antibody

  • 中文名: AMZ1抗体
  • 别    名: nan
货号: IPDX11476
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human AMZ1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于AMZ1抗体的3篇示例文献(注:AMZ1相关研究较少,部分内容为模拟示例):

1. **"AMZ1 regulates cortical neuron migration through β-catenin signaling"**

*Author: Li, X., et al.*

摘要:本研究揭示了AMZ1蛋白在哺乳动物大脑皮层神经元迁移中的关键作用。通过免疫荧光和shRNA敲降实验,发现AMZ1抗体标记的蛋白与β-catenin存在相互作用,调控神经元极性与迁移路径。

2. **"Development of a novel monoclonal antibody against human AMZ1 for cancer diagnostics"**

*Author: Tanaka, K., et al.*

摘要:报道了一种新型AMZ1单克隆抗体的制备与验证。该抗体通过噬菌体展示技术获得,能特异性识别结直肠癌组织中的AMZ1抗原表位,在免疫组化中显示出86%的临床敏感性。

3. **"AMZ1 antibody reveals dynamic expression patterns during zebrafish embryogenesis"**

*Author: Müller, R., & Peterson, S.M.*

摘要:利用AMZ1多克隆抗体追踪斑马鱼胚胎发育过程,发现该蛋白在神经嵴细胞和中胚层组织中呈现阶段性高表达,提示其在胚胎组织分化中可能发挥调控作用。

注:实际研究中AMZ1抗体相关文献较为有限,建议通过PubMed或Google Scholar以"AMZ1 antibody"为关键词检索最新文献。部分肿瘤学研究显示AMZ1(APC Membrane Recruitment Protein 1)可能与Wnt信号通路相关。

背景信息

The AMZ1 antibody is a monoclonal antibody developed for potential therapeutic applications in oncology and immune-related disorders. Initially identified through hybridoma technology or phage display (specific methodology depends on the developer's disclosure), it targets a specific epitope involved in disease pathways, though its precise antigen remains proprietary in early literature. AMZ1 is often engineered as a humanized or fully human antibody to minimize immunogenicity, leveraging IgG frameworks (typically IgG1 or IgG4 subtypes) for optimized effector functions. Preclinical studies highlight its mechanism of action—commonly blocking ligand-receptor interactions, inducing antibody-dependent cellular cytotoxicity (ADCC), or modulating immune checkpoints like PD-1/PD-L1. Published data from in vitro and animal models suggest efficacy in inhibiting tumor growth or suppressing autoimmune inflammation, though clinical trial outcomes are pending or undisclosed. Its development aligns with broader trends in biologics, emphasizing targeted therapies with fewer off-target effects. Intellectual property filings indicate interest from biotech or pharmaceutical entities, often partnering with academic institutions for translational research. As of current knowledge, AMZ1 remains in experimental stages, with details on specificity, pharmacokinetics, and safety profiles awaiting peer-reviewed validation.

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