| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-cell receptor gamma-2 chain C region, T-cell receptor gamma chain C region PT-gamma-1/2, TRGC2, TCRGC2 |
| WB Predicted band size | 21.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TRGC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRGC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TRGC2 (N-term)抗体的假设参考文献示例(注：实际文献需通过学术数据库检索，以下为模拟内容供参考)：
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1. **文献名称**: *"Characterization of TRGC2 expression in human γδ T-cell subsets using a novel N-terminal specific antibody"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对TRGC2蛋白N端的单克隆抗体，通过流式细胞术和免疫印迹验证其特异性，揭示了TRGC2在不同γδ T细胞亚群中的差异性表达模式。
2. **文献名称**: *"TRGC2 as a biomarker for tumor-infiltrating lymphocytes in colorectal cancer"*
**作者**: Li H, et al.
**摘要**: 利用TRGC2 (N-term)抗体进行免疫组化分析，发现TRGC2阳性T细胞在结直肠癌组织中的浸润程度与患者生存率呈正相关，提示其作为预后标志物的潜力。
3. **文献名称**: *"Functional role of TRGC2 in autoimmune disorders: Insights from antibody-mediated depletion studies"*
**作者**: García-Ruiz C, et al.
**摘要**: 通过TRGC2 (N-term)抗体阻断实验，证明TRGC2在类风湿性关节炎患者T细胞中的异常激活可能促进炎症反应，为靶向治疗提供依据。
4. **文献名称**: *"Comparative analysis of TRGC1 and TRGC2 expression across vertebrate species"*
**作者**: Tanaka K, et al.
**摘要**: 采用TRGC2 N端特异性抗体进行跨物种蛋白保守性研究，发现TRGC2在哺乳动物中的表达高度保守，但在禽类中显著缺失，提示其进化功能差异。
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**建议**：实际文献请通过PubMed、Web of Science等平台以关键词“TRGC2 antibody”或“anti-TRGC2 N-terminal”检索，并筛选应用性研究(非商品化抗体说明书)。
The TRGC2 (N-term) antibody targets the N-terminal region of the T-cell receptor gamma constant 2 (TRGC2) protein, a component of the γδ T-cell receptor (TCR) complex. γδ T cells, a subset of T lymphocytes, play critical roles in bridging innate and adaptive immunity, particularly in mucosal tissues, infection responses, and tumor surveillance. The TCR γ chain, encoded by the TRG locus, pairs with the δ chain to form the γδ TCR, which recognizes antigens independently of MHC presentation. TRGC2 is one of the constant region genes within the TRG locus, contributing to the structural stability and signaling of the γδ TCR.
Antibodies specific to TRGC2 (N-term) are valuable tools for studying γδ T-cell development, activation, and function in both physiological and pathological contexts. They are commonly used in techniques like flow cytometry, Western blotting, and immunohistochemistry to detect TRGC2 expression, aiding in the characterization of γδ T-cell subsets in immune responses, autoimmune diseases, and cancers. The N-terminal specificity ensures recognition of intact or truncated TRGC2 variants, helping to differentiate isoforms or assess protein integrity. Research involving this antibody has advanced understanding of γδ T-cell biology, including their roles in infection control, tissue repair, and immunoregulation, while also exploring therapeutic applications targeting γδ T cells in immunotherapy.
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