| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PTRF, Cavin-1, CAVIN1, CAVIN, CGL4, FKSG13, TTF-I interacting peptide 12 |
| Entrez GeneID | 284119; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PTRF (Phospho-Tyr156) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇假设的关于PTRF (Phospho-Tyr156)抗体的参考文献示例(注：内容为虚构，仅作格式参考)：
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1. **文献名称**: *Phosphorylation of PTRF at Tyr156 regulates caveolae dynamics in endothelial cells*
**作者**: Li X, et al.
**摘要**: 本研究报道了PTRF蛋白在Tyr156位点的磷酸化通过调节细胞膜穴样内陷的形成影响内皮细胞迁移。利用新开发的PTRF (Phospho-Tyr156)特异性抗体，通过免疫荧光和Western blot验证了该位点磷酸化与VEGF信号通路的关联。
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2. **文献名称**: *Development of a monoclonal antibody targeting phosphorylated Tyr156 of PTRF and its application in breast cancer*
**作者**: Chen Y, et al.
**摘要**: 作者开发了一种高特异性的抗PTRF (Phospho-Tyr156)单克隆抗体，并通过质谱和肽竞争实验验证其特异性。该抗体在乳腺癌组织样本中检测到异常磷酸化PTRF表达，提示其作为肿瘤生物标志物的潜力。
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3. **文献名称**: *PTRF tyrosine 156 phosphorylation mediates neuronal oxidative stress response*
**作者**: Park S, et al.
**摘要**: 本文发现神经元在氧化应激下PTRF Tyr156位点发生磷酸化，使用Phospho-Tyr156抗体证实该修饰通过激活Nrf2通路增强细胞抗氧化能力，为神经退行性疾病提供了新机制。
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注：以上文献为示例性质，实际研究中请通过PubMed等数据库检索真实文献。
The PTRF (Phospho-Tyr156) antibody is designed to detect the phosphorylated form of PTRF (polymerase I and transcript release factor), also known as Cavin-1. at tyrosine residue 156. PTRF/Cavin-1 is a critical component of caveolae, plasma membrane invaginations involved in signal transduction, lipid homeostasis, and endocytosis. Phosphorylation at Tyr156 is a post-translational modification implicated in regulating PTRF’s function, particularly in response to cellular stress or receptor tyrosine kinase signaling. This modification may influence PTRF’s interaction with other caveolar proteins, such as caveolins, or its role in membrane dynamics and intracellular signaling pathways.
The antibody serves as a tool to study the activation status or regulatory mechanisms of PTRF in physiological and pathological contexts. Dysregulation of PTRF phosphorylation has been linked to metabolic disorders, cancer progression, and cardiovascular diseases, where caveolae-mediated processes are disrupted. Researchers utilize this antibody in techniques like Western blotting, immunofluorescence, or immunoprecipitation to assess Tyr156 phosphorylation levels under specific experimental conditions, such as growth factor stimulation or oxidative stress. Its development aids in elucidating how phosphorylation modulates PTRF’s role in membrane remodeling, mechanotransduction, or lipid metabolism, offering insights into potential therapeutic targets for diseases associated with caveolar dysfunction.
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