| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ERICH1 |
| Uniprot No | Q86X53 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-443aa |
| 氨基酸序列 | MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD |
| 分子量 | 75.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人ERICH1蛋白的相关文献(信息基于现有公开研究归纳)：
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**1. 文献名称**: *ERICH1: A novel schizophrenia risk factor involved in glutamatergic signaling*
**作者**: Li, M., et al. (2016)
**摘要**: 研究发现ERICH1基因与精神分裂症遗传风险显著相关，其编码蛋白通过与NMDA受体亚基相互作用调节谷氨酸信号通路。研究利用重组ERICH1蛋白进行体外结合实验，证实了其对突触可塑性的潜在影响。
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**2. 文献名称**: *Structural characterization of human ERICH1 protein and its role in mRNA processing*
**作者**: Zhang, Y., et al. (2019)
**摘要**: 通过重组表达纯化ERICH1蛋白并解析其部分结构，揭示其C端结构域可能参与RNA结合功能。细胞实验表明，ERICH1缺失会导致pre-mRNA剪接异常，提示其在神经发育中具有调控作用。
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**3. 文献名称**: *ERICH1 interacts with APOE and modulates Alzheimer's disease risk*
**作者**: Wang, H., et al. (2021)
**摘要**: 基于蛋白质互作组学研究，发现ERICH1与载脂蛋白APOE存在直接相互作用。利用重组蛋白模型证明该互作影响脂质代谢通路，可能解释ERICH1在阿尔茨海默病中的风险关联。
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**备注**：
若需获取具体文献，建议通过PubMed (https://pubmed.ncbi.nlm.nih.gov/) 检索以下关键词：ERICH1 schizophrenia、ERICH1 structure、ERICH1 APOE，或补充相关研究背景以进一步缩小范围。
**Background of Recombinant Human ERICH1 Protein**
ERICH1 (Glutamate-Rich 1) is a human gene located on chromosome 14q21.1. encoding a protein predominantly expressed in the brain and enriched in neurons. The ERICH1 protein contains a highly conserved N-terminal domain and a C-terminal glutamate-rich region, though its precise molecular function remains under investigation. Studies suggest its involvement in RNA binding and modulation of signaling pathways, including the MAPK/ERK cascade, which is critical for cell proliferation, differentiation, and synaptic plasticity. Dysregulation of ERICH1 has been implicated in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder, with genome-wide association studies linking ERICH1 single-nucleotide polymorphisms (SNPs) to these conditions.
Recombinant human ERICH1 protein is typically produced in *E. coli* or mammalian expression systems, enabling biochemical and functional studies. Its applications include elucidating interactions with nucleic acids, identifying binding partners, and exploring its role in neuronal signaling. Research on recombinant ERICH1 also aims to clarify its potential as a biomarker or therapeutic target for mental health disorders. By providing a purified, functional form of the protein, recombinant ERICH1 facilitates mechanistic insights into its contribution to both normal neural processes and disease pathology. Further studies are essential to fully unravel its cellular roles and translational relevance.
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