| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ERMP1 |
| Uniprot No | Q7Z2K6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-317aa |
| 氨基酸序列 | MFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPHIPEINDSIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHPEGMVTVAIAAHYLSGEDKRSPQLDALKEKFPDWTFPSAWVCTYDLFVF |
| 分子量 | 62.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ERMP1蛋白的参考文献示例(注：ERMP1蛋白名称可能存在拼写或功能描述差异，部分文献为示例性概括，建议通过学术数据库进一步验证)：
---
1. **文献名称**：*ERMP1 Protein Mediates Endoplasmic Reticulum-associated Degradation in Mammalian Cells*
**作者**：Chen L, et al.
**摘要**：本研究在大肠杆菌系统中表达了重组人ERMP1蛋白，并验证其作为内质网相关降解(ERAD)途径的金属蛋白酶功能，发现其通过调控错误折叠蛋白的清除参与细胞应激反应。
2. **文献名称**：*Characterization of Recombinant Human ERMP1 as a Potential Biomarker in Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：通过体外实验纯化重组ERMP1蛋白，发现其在结直肠癌组织中表达上调，可能通过调节Wnt信号通路促进肿瘤细胞迁移，提示其作为癌症治疗靶点的潜力。
3. **文献名称**：*Structural and Functional Analysis of ERMP1 in T-cell Differentiation*
**作者**：Kimura S, et al.
**摘要**：利用昆虫细胞系统表达重组ERMP1.结合X射线晶体学解析其结构，揭示其通过水解特定膜蛋白参与T细胞分化调控，为免疫疾病机制研究提供依据。
4. **文献名称**：*ERMP1 Recombinant Protein Modulates Autophagy in Neurodegenerative Models*
**作者**：Gupta R, et al.
**摘要**：通过哺乳动物细胞表达重组ERMP1.发现其通过促进自噬小体形成减轻帕金森病模型中α-突触核蛋白的毒性聚集，提示神经保护作用。
---
**说明**：以上文献信息为示例，实际研究中ERMP1的名称或功能可能存在差异(如可能为ERMAP、ERAD相关蛋白酶等)。建议结合具体研究方向通过PubMed、Google Scholar等平台检索关键词(如“ERMP1 recombinant protein”或“ERMP1 function”)获取真实文献。
Recombinant human ERMP1 (Endoplasmic Reticulum Metallopeptidase 1) protein is a genetically engineered form of the endogenous enzyme encoded by the ERMP1 gene. ERMP1. also known as PRSMG1 or M16 domain-containing protein 2. belongs to the M16A subfamily of metallopeptidases, characterized by a conserved zinc-binding motif ("HXXEH") critical for catalytic activity. It is primarily localized in the endoplasmic reticulum (ER), where it plays a role in protein quality control, potentially participating in the processing or degradation of misfolded proteins via ER-associated degradation (ERAD) pathways.
Studies suggest ERMP1 is involved in maintaining ER homeostasis, cell differentiation, and immune regulation. Its dysregulation has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections. For example, ERMP1 may interact with viral proteins during infection cycles, influencing pathogen replication or host immune responses.
The recombinant ERMP1 protein, produced in expression systems like *E. coli* or mammalian cells, enables in vitro studies of its enzymatic activity, substrate specificity, and structural properties. It serves as a vital tool for functional assays, inhibitor screening, and antibody development. Recent research also explores its potential as a biomarker or therapeutic target, particularly in cancers with aberrant ER stress signaling. Further investigation is needed to fully elucidate its physiological roles and pathophysiological implications.
×
