| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM130A2 |
| Uniprot No | Q8WYN3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-585aa |
| 氨基酸序列 | MSGILKRKFEEVDGSSPCSSVRESDDEVSSSESADSGDSVNPSTSSHFTPSSILKREKRLRTKNVHFSCVTVYYFTRRQGFTSVPSQGGSTLGMSSRHNSVRQYTLGEFAREQERLHREMLREHLREEKLNSLKLKMTKNGTVESEEASTLTLDDISDDDIDLDNTEVDEYFFLQPLPTKKRRALLRASGVKKIDVEEKHELRAIRLSREDCGCDCRVFCDPDTCTCSLAGIKCQVDRMSFPCGCTKEGCSNTAGRIEFNPIRVRTHFLHTIMKLELEKNREQQIPTLNGCHSEISAHSSSMGPVAHSVEYSIADSFEIETEPQAAVLHLQSAEELDCQGEEEEEEEDGSSFCSGVTDSSTQSLAPSESDEEEEEEEEEEEEEDDDDDKGDGFVEGLGTHAEVVPLPSVLCYSDGTAVHESHAKNASFYANSSTLYYQIDSHIPGTPNQISENYSERDTVKNGTLSLVPYTMTPEQFVDYARQAEEAYGASHYPAANPSVIVCCSSSENDSGVPCNSLYPEHRSNHPQVEFHSYLKGPSQEGFVSALNGDSHISEHPAENSLSLAEKSILHEECIKSPVVETVPV |
| 分子量 | 91.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为假设性示例，具体文献需通过学术数据库验证：
1. **文献名称**：FAM130A2 promotes lung adenocarcinoma progression by regulating EGFR signaling
**作者**：Zhang Y. et al. (2021)
**摘要**：通过重组FAM130A2蛋白功能实验，发现其通过激活EGFR信号通路促进肺癌细胞迁移和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**：Structural insights into FAM130A2 binding to the PI3K regulatory subunit
**作者**：Li X. et al. (2019)
**摘要**：利用重组人FAM130A2蛋白进行晶体结构解析，揭示了其与PI3K p85亚基的互作界面，为靶向药物设计提供结构基础。
3. **文献名称**：FAM130A2 regulates neuronal differentiation via Wnt/β-catenin pathway
**作者**：Wang L. et al. (2020)
**摘要**：体外实验显示，重组FAM130A2蛋白通过调控Wnt通路影响神经干细胞定向分化，提示其在神经发育中的作用。
4. **文献名称**：Optimization of recombinant FAM130A2 expression in HEK293 cells
**作者**：Chen H. et al. (2018)
**摘要**：系统性优化重组FAM130A2在哺乳动物系统中的表达与纯化流程，为功能性研究提供高产量蛋白制备方案。
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**提示**：
- FAM130A2研究目前较为局限，真实文献可能较少，建议扩大关键词(如“FAM130A家族”或相关通路)搜索。
- 可关注Cell Signaling、Cancer Research等期刊近期文章，或预印本平台(bioRxiv)获取最新进展。
- 蛋白功能可能与细胞骨架调控、肿瘤转移相关，可结合这些方向筛选文献。
Recombinant human FAM130A2 protein is a genetically engineered form of the FAM130A2 (Family with Sequence Similarity 130 Member A2) protein, designed to facilitate functional and structural studies. FAM130A2. encoded by the FAM130A2 gene, is a relatively understudied protein with proposed roles in cellular signaling, adhesion, and cytoskeletal organization. It contains conserved domains suggesting potential interactions with other proteins or nucleic acids, though its exact molecular mechanisms remain unclear.
Research indicates FAM130A2 may influence cell proliferation and survival pathways, with possible links to cancer progression and metastasis. Its expression has been detected in various tissues, including the brain, liver, and kidney, hinting at diverse physiological functions. Recombinant FAM130A2 is typically produced in heterologous expression systems (e.g., E. coli, mammalian cells) to ensure proper post-translational modifications and solubility. This enables applications such as antibody development, biochemical assays, and pathway mapping. Studying this protein could elucidate its role in diseases like neurodevelopmental disorders or carcinomas, making it a target for therapeutic exploration. Despite limited characterization, FAM130A2’s conserved sequence across species underscores its biological relevance, warranting further investigation into its regulatory networks and disease associations.
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