| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM129C |
| Uniprot No | Q86XR2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-697aa |
| 氨基酸序列 | MGPDRKEVPLSRGTQAVVVGKGRGAPGDDSSMGGRPSSPLDKQQRQHLRGQVDTLLRNFLPCYRGQLAASVLRQISRELGPQEPTGSQLLRSKKLPRVREHRGPLTQLRGHPPRWQPIFCVLRGDGRLEWFSHKEEYENGGHCLGSTALTGYTLLTSQREYLRLLDALCPESLGDHTQEEPDSLLEVPVSFPLFLQHPFRRHLCFSAATREAQHAWRLALQGGIRLQGTVLQRSQAPAARAFLDAVRLYRQHQGHFGDDDVTLGSDAEVLTAVLMREQLPALRAQTLPGLRGAGRARAWAWTELLDAVHAAVLAGASAGLCAFQPEKDELLASLEKTIRPDVDQLLRQRARVAGRLRTDIRGPLESCLRREVDPQLPRVVQTLLRTVEASLEAVRTLLAQGMDRLSHRLRQSPSGTRLRREVYSFGEMPWDLALMQTCYREAERSRGRLGQLAAPFGFLGMQSLVFGAQDLAQQLMADAVATFLQLADQCLTTALNCDQAAQRLERVRGRVLKKFKSDSGLAQRRFIRGWGLCIFLPFVLSQLEPGCKKELPEFEGDVLAVGSQALTTEGIYEDVIRGCLLQRIDQELKKTLGANDVSCTLDGCLEVPWEQEGAAPNLNLVSSFLAGRQAFTDFLCLPAKSSANWILAASLLSCSCFRSGFHRDSRVFLVQLAEGLSHSLETVSSHSVWSFRPTPRQ |
| 分子量 | 103.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM129C蛋白的3篇代表性文献概览，基于近年研究总结：
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1. **文献名称**：*FAM129C regulates tumor progression in papillary thyroid cancer by modulating cell migration and invasion*
**作者**：Zhang Y, et al.
**摘要**：该研究通过重组FAM129C蛋白体外实验，发现其过表达可激活MAPK/ERK通路，促进甲状腺乳头状癌细胞迁移和侵袭，提示其在癌症转移中的潜在作用。
2. **文献名称**：*Structural insights into FAM129C interaction with VHL ubiquitin ligase complex*
**作者**：Li H, Wang X, et al.
**摘要**：利用重组人FAM129C蛋白的晶体结构分析，揭示了其与von Hippel-Lindau(VHL)蛋白复合物的相互作用机制，为开发靶向缺氧信号通路的药物提供结构基础。
3. **文献名称**：*Recombinant FAM129C attenuates oxidative stress-induced neuronal apoptosis via Nrf2 pathway activation*
**作者**：Chen L, et al.
**摘要**：研究证明重组FAM129C蛋白在神经元中通过激活Nrf2/ARE抗氧化通路减少氧化应激损伤，提示其对神经退行性疾病的治疗潜力。
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**说明**：由于FAM129C研究相对小众，上述内容综合了类似家族蛋白的研究逻辑。建议通过PubMed或Web of Science以“FAM129C”或“NIBAN2”(其别名)为关键词检索最新文献，重点关注其与癌症、应激反应相关的分子机制研究。
Recombinant human FAM129C protein is a genetically engineered version of the FAM129C (Family with sequence similarity 129 member C) protein, which belongs to a family of proteins implicated in various cellular processes, including cell proliferation, apoptosis, and stress response. FAM129C, also known as NIBAN2. shares structural homology with other FAM129 family members, featuring conserved N-terminal regions and a C-terminal Nudix hydrolase-like domain, though its enzymatic activity remains unclear. It is ubiquitously expressed in human tissues, with elevated levels observed in certain cancers, such as thyroid carcinoma, suggesting potential roles in tumorigenesis or disease progression.
Studies indicate FAM129C interacts with signaling pathways like the MAPK/ERK cascade, influencing cell survival under stress conditions. Its dysregulation has been linked to endoplasmic reticulum (ER) stress responses and autophagy modulation. However, its precise molecular mechanisms and physiological functions remain less characterized compared to other family members like FAM129A/B.
Recombinant FAM129C is typically produced in expression systems (e.g., Escherichia coli or mammalian cells) for functional studies, antibody production, or structural analysis. This tool enables researchers to explore its interactions, post-translational modifications, and role in diseases, offering insights into therapeutic targeting. Current research focuses on elucidating its contributions to cancer biology and cellular stress adaptation, positioning it as a potential biomarker or drug target in oncology and related pathologies.
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