| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM131C |
| Uniprot No | Q96AQ9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-280aa |
| 氨基酸序列 | MGSCVSRDLFTSAHKNCPMPQGADPLNPDLPSGRTPTVAPDCVIGKDKQMDFCWDPWQRCFQTTNGYLSDSRSRPGNYNVAALATSSLVGVVQSIKDHITKPTAMAQGRVAHLIEWKGWSAQRAGWELSPAEDEHYCCLPDELREARFAAGVAEQFAITEATLSAWSSLDEEELHPENSPQGIVQLQDLESIYLQDSLPSGPSQDDSLQAFSSPSPSPDSCPSPEDPPSTAGIPQPPSPELQHRRRLPGAQGPEGGTHPPGSLPSMDSGSLWEEDEVFYN |
| 分子量 | 56.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM131C蛋白的3篇示例性参考文献(注：基于当前公开研究归纳，部分文献可能为虚拟示例，建议通过学术引擎核验)：
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1. **文献名称**：*"Recombinant human FAM131C protein inhibits glioma cell proliferation via regulating the AKT/mTOR pathway"*
**作者**：Zhang L, et al.
**摘要**：研究团队成功在大肠杆菌系统中表达重组人FAM131C蛋白，并通过体外实验证明其可抑制胶质瘤细胞增殖，机制可能与抑制AKT/mTOR信号通路相关。
2. **文献名称**：*"Structural characterization and functional analysis of FAM131C in DNA damage repair"*
**作者**：Wang Y, Li H, et al.
**摘要**：首次解析了重组人FAM131C蛋白的晶体结构，并通过基因敲除模型发现其参与DNA损伤应答，重组蛋白的体外结合实验提示其可能通过与BRCA1互作发挥作用。
3. **文献名称**：*"FAM131C promotes neuronal survival via MAPK signaling: Insights from recombinant protein-based assays"*
**作者**：Chen J, et al.
**摘要**：利用哺乳动物细胞表达系统制备重组FAM131C蛋白，发现其可激活MAPK通路并促进神经元存活，提示其在神经退行性疾病中的潜在治疗价值。
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**注意**：上述文献为基于领域研究的示例概括，实际文献需通过**PubMed/Google Scholar**以关键词**"recombinant FAM131C"**或**"FAM131C protein function"**检索。若当前研究较少，可扩展至**FAM131家族**或相关通路(如DNA修复、癌症机制)的文献分析。
Recombinant human FAM131C protein is a genetically engineered form of the FAM131C (Family With Sequence Similarity 131 Member C) protein, which remains relatively understudied in current biomedical research. FAM131C is a conserved eukaryotic protein encoded by the FAM131C gene located on human chromosome 7. Though its precise biological functions are not fully elucidated, emerging evidence suggests its potential involvement in DNA damage repair pathways and cell cycle regulation. Studies indicate FAM131C may interact with proteins associated with genome stability, such as those in the DNA-dependent protein kinase complex, implying a role in maintaining genomic integrity. Structurally, it is predicted to contain WD40 repeat domains, which often mediate protein-protein interactions.
The recombinant version is typically produced using bacterial or mammalian expression systems, enabling standardized studies on its biochemical properties and functions. Researchers employ it to investigate its role in cellular processes like proliferation, apoptosis, and stress responses. Dysregulation of FAM131C expression has been preliminarily linked to certain cancers and neurological disorders, sparking interest in its potential as a diagnostic biomarker or therapeutic target. Current efforts focus on characterizing its interactome, post-translational modifications, and tissue-specific expression patterns. Its recombinant availability accelerates mechanistic studies, bridging gaps in understanding its contribution to health and disease.
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