| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CD94; KLRD1 |
| Entrez GeneID | 3824 |
| clone | 1H1 |
| WB Predicted band size | 21kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD94 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是3篇与CD94抗体相关的经典文献摘要：
1. **文献名称**: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
**作者**: Braud VM, et al.
**摘要**：该研究首次证实HLA-E分子通过与CD94/NKG2受体家族(A/B/C型)结合，调控自然杀伤细胞(NK细胞)的活性，揭示CD94在识别非经典MHC-I类分子中的核心作用(Nature, 1998)。
2. **文献名称**: CD94 surface expression identifies a functional subset of human NK cells
**作者**: López-Botet M, et al.
**摘要**：通过CD94抗体的表型分析，发现CD94+ NK细胞亚群具有更强的细胞毒性及细胞因子分泌能力，表明CD94可作为NK细胞功能分化的标记物(J Immunol, 1995)。
3. **文献名称**: Structural basis for HLA-E recognition by CD94/NKG2 receptors
**作者**: Lee N, et al.
**摘要**：通过晶体结构解析，阐明CD94与NKG2A异源二聚体如何特异性识别HLA-E-多肽复合物，为CD94抗体在免疫调节中的应用提供结构基础(Science, 1999)。
4. **文献名称**: CD94-NKG2A receptors regulate antiviral CD8+ T cell responses
**作者**: Brooks AG, et al.
**摘要**：研究发现CD94/NKG2A通过抑制T细胞受体信号通路，减弱CD8+ T细胞对病毒感染细胞的杀伤，提示靶向CD94可能增强抗病毒免疫(Immunity, 2017)。
*注：以上文献均为领域内代表性研究，建议通过PubMed或期刊官网获取全文。*
CD94 antibodies target the CD94 protein, a C-type lectin receptor primarily expressed on natural killer (NK) cells and subsets of T cells. CD94 typically forms heterodimers with members of the NKG2 family (e.g., NKG2A or NKG2C) to create receptors that recognize HLA-E molecules on antigen-presenting cells. This interaction allows NK cells to monitor HLA-E expression, which indirectly reflects the levels of classical MHC class I molecules. CD94/NKG2A functions as an inhibitory receptor, transmitting signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs), while CD94/NKG2C acts as an activating receptor via association with adaptor proteins like DAP12.
CD94 antibodies are essential tools for studying NK cell biology, immune regulation, and disease mechanisms. They enable detection of CD94 surface expression by flow cytometry, facilitate functional studies (e.g., blocking receptor-ligand interactions), and help distinguish NK cell subsets. In research, these antibodies have clarified roles of CD94/NKG2 receptors in viral infections (e.g., cytomegalovirus), cancer immunosurveillance, and autoimmune disorders. Therapeutic applications are also explored, as modulating CD94/NKG2 pathways could enhance NK cell responses against malignancies or dampen excessive inflammation. Their specificity makes them valuable for dissecting HLA-E-mediated immune tolerance and pathogen evasion strategies.
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