Mouse Monoclonal APBB1IP Antibody

The APBB1IP (Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein) antibody is a tool used to study the APBB1IP protein, also known as RAP1GAP, which plays roles in cell adhesion, migration, and signaling. This protein interacts with the amyloid precursor protein (APP) and regulates RAP1. a small GTPase involved in integrin-mediated cell adhesion and cytoskeletal reorganization. APBB1IP is implicated in diverse biological processes, including immune response, angiogenesis, and cancer metastasis. Antibodies targeting APBB1IP enable researchers to detect its expression, localization, and interactions in various experimental settings, such as Western blotting, immunoprecipitation, and immunofluorescence. These antibodies are often produced in hosts like rabbits or mice, with validation in knockout (KO) models to ensure specificity. APBB1IP's association with diseases, particularly cancer (e.g., tumor invasion) and neurological disorders (e.g., Alzheimer’s disease due to APP links), makes its study clinically relevant. Researchers use these antibodies to explore mechanisms underlying metastasis, inflammation, and neuronal pathology, providing insights into therapeutic targets. Commercial APBB1IP antibodies are widely available, supporting both basic research and drug development efforts.