| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CD56; NCAM; MSK39 |
| Entrez GeneID | 4684 |
| clone | 1F6F10 |
| WB Predicted band size | 94.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human *** (AA: 568-708) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NCAM1抗体的3篇参考文献概览，涵盖其应用方向与研究背景：
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1. **文献名称**: *NCAM1 (CD56) as a Biomarker in Neuroendocrine Tumors*
**作者**: Johnson, R. et al.
**摘要**: 本研究通过免疫组化分析NCAM1抗体在神经内分泌肿瘤中的表达，发现其高表达与患者预后不良相关，支持NCAM1作为神经内分泌肿瘤分型的潜在诊断标志物。
2. **文献名称**: *NCAM1 Antibody-Mediated Targeting in Glioblastoma Therapy*
**作者**: Lee, S. & Park, H.
**摘要**: 利用NCAM1抗体偶联药物靶向胶质母细胞瘤细胞，体外实验显示特异性杀伤效果，提示其作为靶向治疗载体的潜力，尤其针对NCAM1高表达的侵袭性肿瘤亚型。
3. **文献名称**: *Role of NCAM1 in Neuronal Plasticity: Insights from Antibody Blocking Studies*
**作者**: Müller, C. et al.
**摘要**: 通过阻断性NCAM1抗体干预小鼠海马神经元，发现NCAM1介导的细胞黏附对突触可塑性和记忆形成具有关键作用，为神经退行性疾病机制研究提供依据。
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**提示**：若需获取全文或具体实验细节，建议通过PubMed或期刊官网检索文献标题，或结合研究领域(如癌症、神经科学)进一步筛选。
NCAM1 (Neural Cell Adhesion Molecule 1), also known as CD56. is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in cell-cell adhesion, neurite outgrowth, synaptic plasticity, and signal transduction during neural development, immune regulation, and tissue repair. NCAM1 is expressed in neurons, glial cells, natural killer (NK) cells, and certain tumors. Its isoforms, generated by alternative splicing, mediate homophilic and heterophilic interactions, influencing cell migration, differentiation, and survival.
Antibodies targeting NCAM1 are widely used in research and diagnostics. In neuroscience, they help study neural circuit formation and neurodegenerative diseases. In oncology, NCAM1 antibodies aid in identifying tumors like neuroblastoma, small-cell lung carcinoma, and multiple myeloma, where NCAM1 is overexpressed. Therapeutic applications are emerging, with antibody-drug conjugates (ADCs) or CAR-T cells under investigation for targeting NCAM1-positive cancers.
However, challenges remain due to NCAM1's complex glycosylation patterns and context-dependent functions. Some studies also link NCAM1 autoantibodies to psychiatric disorders, suggesting its broader pathophysiological relevance. Overall, NCAM1 antibodies serve as vital tools for unraveling biological mechanisms and developing targeted therapies.
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