| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL21R; NILR; IMD56 |
| Entrez GeneID | 50615 |
| clone | 8H10G4D12 |
| WB Predicted band size | 59.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD360 (AA: extra 20-232) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD360抗体的3篇示例参考文献(注：CD360相关研究较为有限，以下内容为模拟示例，实际文献需通过学术数据库核实)：
1. **文献名称**：*CD360 (TNFRSF9) Antibody Enhances T-cell Activation in Chronic Viral Infection*
**作者**：Smith A, et al.
**摘要**：研究CD360抗体对T细胞共刺激的作用，发现其可增强病毒感染模型中的T细胞增殖与细胞因子分泌，提示其在免疫疗法中的潜在应用。
2. **文献名称**：*Targeting CD360 with Monoclonal Antibodies Suppresses Autoimmune Pathology in Murine Models*
**作者**：Zhang L, et al.
**摘要**：通过动物实验证明，抗CD360抗体能选择性抑制过度活化的B细胞，缓解类风湿性关节炎模型的炎症反应，为自身免疫疾病治疗提供新策略。
3. **文献名称**：*Structural and Functional Characterization of a Novel Anti-CD360 Antibody for Cancer Immunotherapy*
**作者**：Brown K, et al.
**摘要**：报道一种高亲和力抗CD360单克隆抗体的开发，解析其与CD360的结合表位，并在体外实验中证实其增强NK细胞杀伤肿瘤细胞的能力。
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**注意**：CD360的研究文献较少，可能与TNFRSF9(4-1BB)等分子存在关联。建议通过PubMed或Google Scholar以“CD360 antibody”或“TNFRSF9 therapeutic antibody”等关键词检索最新成果。若需具体文献，请提供更详细信息以便精准查找。
CD360 antibody targets CD360. a cell surface molecule belonging to the T-cell immunoglobulin and mucin (TIM) family, primarily expressed on immune cells like T cells, natural killer (NK) cells, and antigen-presenting cells. Initially identified for its role in immune regulation, CD360 (also known as TIM-family member) is implicated in modulating immune activation and tolerance. Structurally, it contains an immunoglobulin variable domain and a mucin-like region, enabling interactions with ligands such as phosphatidylserine, which is exposed on apoptotic cells. This interaction suggests a role in phagocytosis and clearance of cellular debris, linking CD360 to homeostasis and immune response modulation.
Research highlights CD360's dual role in immunity: it can promote pro-inflammatory responses in certain contexts while suppressing immune activity in others, depending on ligand engagement and cellular environment. Dysregulation of CD360 signaling is associated with autoimmune diseases, chronic infections, and cancer, where its overexpression or inhibition correlates with disease progression. Therapeutic antibodies targeting CD360 aim to either block or enhance its signaling to restore immune balance. Preclinical studies explore its potential in treating malignancies and autoimmune disorders, positioning CD360 as a promising immunotherapeutic target. Further research is needed to fully elucidate its mechanistic pathways and clinical applications.
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