| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SAA; PIG4; SAA2; TP53I4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SAA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SAA1抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*"Serum amyloid A1 as a biomarker for disease activity and anti-SAA1 antibody as a therapeutic agent in autoimmune diseases"*
**作者**：Kimura T, et al.
**摘要**：研究探讨了SAA1在类风湿性关节炎等自身免疫疾病中的表达水平，并开发了针对SAA1的单克隆抗体。实验表明，该抗体通过抑制SAA1介导的炎症信号通路，显著减轻小鼠模型中的关节损伤。
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2. **文献名称**：*"Development of a high-affinity anti-SAA1 antibody for early diagnosis of acute kidney injury"*
**作者**：Zhang L, et al.
**摘要**：研究团队通过噬菌体展示技术筛选出高特异性抗SAA1抗体，验证其在急性肾损伤患者血清中的检测灵敏性。结果显示，该抗体可识别低浓度SAA1.为临床早期诊断提供了新工具。
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3. **文献名称**：*"SAA1 promotes tumor metastasis via TLR4-mediated EMT and is targeted by a neutralizing antibody in colorectal cancer"*
**作者**：Wang Y, et al.
**摘要**：本文揭示了SAA1通过激活TLR4通路诱导结直肠癌细胞上皮间质转化(EMT)，促进转移。研究者开发的中和抗体在小鼠模型中有效抑制肿瘤扩散，提示其潜在治疗价值。
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如需具体文献来源(期刊、年份等)，可进一步提供关键词或数据库检索支持。
**Background of SAA1 Antibody**
Serum Amyloid A1 (SAA1) is a highly conserved acute-phase reactant primarily synthesized in the liver and secreted into circulation during inflammatory responses. It belongs to the SAA family, which includes isoforms involved in lipid metabolism, immune regulation, and tissue repair. SAA1 levels rise dramatically (up to 1.000-fold) during infection, trauma, or chronic inflammation, driven by cytokines like IL-6. IL-1β, and TNF-α.
SAA1 plays dual roles: as an apolipoprotein in HDL metabolism and as a pro-inflammatory mediator promoting leukocyte recruitment, cytokine release, and extracellular matrix remodeling. Its chronic overexpression is linked to amyloidosis, atherosclerosis, rheumatoid arthritis, and cancer metastasis.
Antibodies targeting SAA1 are critical tools for research and diagnostics. They enable quantification of SAA1 in clinical samples (e.g., ELISA, immunohistochemistry) to monitor disease activity or infection severity. In research, SAA1 antibodies help elucidate its signaling pathways, including interactions with Toll-like receptors (TLR2/4) and receptor for advanced glycation end products (RAGE). Therapeutic applications are also explored, with neutralizing antibodies investigated for mitigating SAA1-driven inflammation or amyloid deposition.
Despite its clinical relevance, SAA1's precise mechanisms remain partially understood, driving ongoing studies to define its role in inflammation-resolution balance and tissue-specific pathologies.
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