| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SEC11A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SEC11A抗体的3篇参考文献的简要列举，供参考：
1. **文献名称**：*"SEC11A is a critical regulator of oncogenic KRAS in pancreatic ductal adenocarcinoma"*
**作者**：Li et al.
**摘要**：研究揭示了SEC11A在胰腺癌中通过调控KRAS信号通路促进肿瘤生长的作用。该文献使用SEC11A抗体进行Western blot和免疫组化实验，证实其在癌组织中高表达，并与患者预后相关。
2. **文献名称**：*"The role of SEC11A in the mammalian secretory pathway investigated by CRISPR-Cas9 knockout models"*
**作者**：Saito et al.
**摘要**：通过基因编辑技术敲除SEC11A，发现其缺失导致内质网应激和分泌蛋白加工异常。研究利用特异性SEC11A抗体验证蛋白表达缺失，并探讨其在分泌途径中的关键功能。
3. **文献名称**：*"Development and validation of a novel SEC11A monoclonal antibody for immunohistochemical analysis in human tissues"*
**作者**：Wang et al.
**摘要**：报道了一种新型SEC11A单克隆抗体的开发与验证，该抗体在多种组织样本中表现出高特异性，适用于免疫组织化学和流式细胞术，为相关疾病研究提供工具。
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**备注**：若需获取全文或更多文献，建议通过PubMed或学术数据库(如Google Scholar)以关键词“SEC11A antibody”或“SEC11A function”检索近年研究。部分文献可能需要订阅访问权限。
The SEC11A antibody targets SEC11 homolog A, a critical component of the signal peptidase complex (SPC) in the endoplasmic reticulum (ER). SEC11A, a serine protease, plays a key role in protein processing by cleaving N-terminal signal peptides from nascent secretory and membrane proteins during their translocation into the ER. This cleavage is essential for proper protein maturation, trafficking, and secretion. The SPC, comprising subunits like SEC11A, SEC11B (in mammals), and SPCS1-3. ensures accurate signal peptide removal, influencing cellular homeostasis and secretion pathways.
SEC11A antibodies are widely used in research to study protein secretion mechanisms, ER function, and diseases linked to secretory defects, such as certain cancers or genetic disorders. They enable detection of SEC11A expression via techniques like Western blotting, immunofluorescence, or immunohistochemistry, helping visualize its subcellular localization and abundance. Studies using these antibodies have elucidated SEC11A's role in adaptive ER expansion under stress and its interaction with other SPC components. Additionally, SEC11A dysregulation has been implicated in pathological conditions, making its antibody a valuable tool for exploring molecular bases of secretion-related diseases and potential therapeutic targets.
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