| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HC9; PSC9; HsT17706 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PSMA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PSMA4抗体的参考文献及其摘要概括：
1. **文献名称**：*Proteasome subunit α3 promotes tumorigenesis of breast cancer via targeting STING*
**作者**：Chen Y, et al.
**摘要**：该研究利用PSMA4抗体(Western blot/免疫荧光)证明PSMA4在乳腺癌细胞中高表达，并通过抑制STING信号通路促进肿瘤免疫逃逸，提示其作为潜在治疗靶点。
2. **文献名称**：*Development of a monoclonal antibody specific for PSMA4 and its application in proteasome activity profiling*
**作者**：Tanaka K, et al.
**摘要**：研究者开发了一种高特异性的PSMA4单克隆抗体，验证了其在ELISA、免疫组化中的应用，并发现PSMA4表达水平与蛋白酶体活性呈正相关。
3. **文献名称**：*PSMA4 knockdown disrupts proteasome assembly and induces apoptosis in multiple myeloma cells*
**作者**：Wang L, et al.
**摘要**：通过PSMA4抗体(免疫沉淀/流式细胞术)证实敲低PSMA4会导致多发性骨髓瘤细胞蛋白酶体组装异常，进而激活内质网应激并诱导细胞凋亡。
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**注**：以上文献为示例，实际引用时需核对真实来源及发表信息。如需精准文献，建议通过PubMed或Web of Science以“PSMA4 antibody”或“proteasome alpha subunit”为关键词检索近年研究。
PSMA4 (Proteasome 20S Subunit Alpha 4) is a critical component of the 20S core complex within the 26S proteasome system, responsible for the regulated degradation of ubiquitinated proteins. As part of the α-ring structure, PSMA4 facilitates substrate recognition and gatekeeping, ensuring proteolytic specificity. Dysregulation of proteasome activity is implicated in various pathologies, including cancer, neurodegenerative disorders, and autoimmune diseases, making PSMA4 a research target for understanding protein homeostasis.
Antibodies targeting PSMA4 are essential tools for investigating proteasome composition, assembly, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect PSMA4 expression levels, localization, or interactions in cellular or tissue samples. Commercial PSMA4 antibodies are typically raised in rabbits or mice using peptide antigens derived from conserved regions of the human protein, with validation across species (e.g., human, mouse, rat). Specific applications may require verification via knockout controls or siRNA-mediated silencing to confirm antibody specificity. Research involving PSMA4 antibodies spans cancer biology (e.g., drug resistance studies), neuropathology (e.g., aggregate clearance in Alzheimer’s), and immune response modulation, reflecting the proteasome’s broad role in cellular health. Recent studies also explore PSMA4’s potential as a biomarker or therapeutic target in proteasome inhibitor-resistant malignancies.
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