| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GRG6; PREMBL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TLE6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TLE6抗体的3篇示例参考文献(注：以下内容为示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*"TLE6 is essential for early embryonic development and mediates cortical granule exocytosis"*
**作者**：Wang, Y., et al.
**摘要**：本研究通过特异性TLE6抗体检测发现，TLE6在小鼠卵母细胞和早期胚胎中高表达，并证实其通过调控皮质颗粒释放影响胚胎着床前发育。
2. **文献名称**：*"Characterization of a novel monoclonal antibody against human TLE6 and its application in ovarian cancer diagnostics"*
**作者**：Chen, L., et al.
**摘要**：团队开发了一种高特异性抗人TLE6单克隆抗体，验证其在免疫组化(IHC)和Western blot中的有效性，并发现TLE6在卵巢癌组织中异常高表达。
3. **文献名称**：*"The role of TLE6 in Wnt signaling pathway regulation during neural crest cell migration"*
**作者**：Garcia, R., et al.
**摘要**：利用TLE6抗体进行功能抑制实验，揭示TLE6通过抑制Wnt/β-catenin通路调控神经嵴细胞迁移的分子机制。
建议通过 **PubMed** 或 **Google Scholar** 搜索关键词“TLE6 antibody”、“TLE6 function”获取真实文献。
The TLE6 antibody targets the Transducin-like enhancer of split 6 (TLE6) protein, a member of the Groucho/TLE family of transcriptional corepressors. These proteins lack DNA-binding domains but interact with transcription factors to modulate gene expression, primarily through chromatin remodeling and recruitment of histone deacetylases. TLE6 is distinct from other TLE family members due to its specific role in embryonic development, particularly in oocytes and early embryos. It is critical for cell polarity, spindle assembly, and asymmetric cell division during mammalian preimplantation development.
TLE6 forms a subcortical maternal complex (SCM) with other proteins like MATER and FILIA, essential for zygotic genome activation and embryogenesis. Mutations in TLE6 are linked to female infertility and early embryonic arrest in humans. Research on TLE6 antibodies focuses on elucidating its expression patterns, localization, and interactions in developmental models. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein dynamics in reproductive biology and stem cell research.
Commercial TLE6 antibodies are typically monoclonal or polyclonal, validated for specificity in human, mouse, or rat samples. Their applications extend to investigating molecular mechanisms underlying developmental disorders and improving assisted reproductive technologies.
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