Rabbit Polyclonal EMC1 Antibody

中文名： EMC1抗体
别名： CAVIPMR; KIAA0090

货号: IPDX02969

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/30-1/150	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	CAVIPMR; KIAA0090
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human EMC1
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02969(EMC1 Antibody) at dilution 1/35. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02969(EMC1 Antibody) at dilution 1/35. (Original magnification: ×200)

参考文献

以下是关于EMC1抗体的3篇文献示例(文献信息为虚构，仅供格式参考)：

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1. **文献名称**: *EMC1 is essential for endoplasmic reticulum-associated degradation and protein quality control*

**作者**: Smith A, et al.

**摘要**: 本研究利用针对EMC1的特异性抗体，通过免疫沉淀和Western blot技术，揭示了EMC1在内质网相关降解(ERAD)中的作用。实验表明，EMC1缺失会导致错误折叠蛋白的积累，并激活未折叠蛋白反应(UPR)。

2. **文献名称**: *Structural characterization of the EMC complex using cryo-EM and monoclonal antibodies*

**作者**: Chen L, et al.

**摘要**: 作者开发了一种高亲和力的EMC1单克隆抗体，结合冷冻电镜技术解析了EMC复合体的三维结构。研究发现EMC1的跨膜结构域对复合体稳定性至关重要，抗体阻断实验进一步验证了其功能位点。

3. **文献名称**: *EMC1 mutations disrupt cortical neurogenesis and are linked to human neurodevelopmental disorders*

**作者**: Wang Y, et al.

**摘要**: 通过免疫荧光染色(使用EMC1多克隆抗体)，发现EMC1基因突变会破坏小鼠皮层神经干细胞的增殖与分化。临床数据分析表明，EMC1异常与人类智力障碍和自闭症谱系障碍相关。

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注：以上文献为示例，实际研究中请通过PubMed或Google Scholar检索真实文献。若需具体论文，可尝试搜索关键词“EMC1 antibody”、“EMC1 function”或结合研究领域(如神经科学、癌症生物学)。

背景信息

The EMC1 (ER Membrane Protein Complex Subunit 1) antibody is a research tool used to study the EMC, a conserved multi-protein complex localized in the endoplasmic reticulum (ER). The EMC plays a critical role in membrane protein biogenesis, facilitating the proper folding, assembly, and stability of transmembrane proteins. EMC1. the largest subunit, is essential for the structural integrity of the complex and its function in coordinating post-translational processes. Dysregulation of EMC1 has been linked to neurological disorders, including cerebellar atrophy, intellectual disability, and retinitis pigmentosa, as well as cancers, where aberrant ER protein homeostasis contributes to tumor progression.

Antibodies targeting EMC1 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. These studies help elucidate mechanisms underlying EMC-associated pathologies, such as disrupted ER stress responses or defective membrane protein trafficking. Recent work also explores EMC1's role in viral infections, as some pathogens exploit ER machinery for replication.

Overall, EMC1 antibodies serve as vital reagents for advancing understanding of ER biology, disease mechanisms, and potential therapeutic strategies targeting protein quality control pathways.