Rabbit Polyclonal LMO3 Antibody

The LMO3 antibody is a research tool designed to detect LIM domain-only protein 3 (LMO3), a member of the LMO family of transcriptional regulators. LMO proteins are characterized by two LIM domains, which mediate protein-protein interactions and play roles in cell differentiation, development, and oncogenesis. LMO3. encoded by the *LMO3* gene on human chromosome 12p12.2. is primarily expressed in the central nervous system and has been implicated in neurodevelopmental processes. Notably, LMO3 gained attention due to its oncogenic potential. Studies link its overexpression to aggressive neuroblastoma, where it interacts with neuronal transcription factors like ASCL1 to drive tumor progression. It is also associated with poor prognosis in lung adenocarcinoma and other cancers. The LMO3 antibody enables researchers to investigate its expression patterns, subcellular localization, and interactions in both normal and pathological contexts. While LMO3 shares structural homology with LMO1 and LMO2 (known oncogenes in T-cell leukemia), its tissue-specific roles and mechanisms remain distinct. Current research focuses on validating LMO3 as a diagnostic or prognostic biomarker and exploring its therapeutic targeting. However, challenges include understanding context-dependent functions and optimizing antibody specificity across experimental platforms (e.g., immunohistochemistry, Western blot). Overall, the LMO3 antibody serves as a critical reagent for unraveling the biological and clinical significance of this understudied protein.