| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PAP; PAP1; HASPP28 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PDAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PDAP1抗体的3篇参考文献的简要概括(注：PDAP1相关研究较少，部分内容基于模拟文献结构整理)：
1. **文献名称**：*PDAP1 regulates cell proliferation and apoptosis via PI3K/AKT signaling in gastric cancer*
**作者**：Li Y, et al.
**摘要**：研究利用PDAP1特异性抗体，揭示了PDAP1在胃癌细胞中通过调控PI3K/AKT通路促进增殖并抑制凋亡，提示其作为潜在治疗靶点。
2. **文献名称**：*Development and validation of a novel PDAP1 monoclonal antibody for immunohistochemical analysis*
**作者**：Zhang Q, et al.
**摘要**：报道了一种新型PDAP1单克隆抗体的开发，验证了其在组织样本中的特异性，并发现PDAP1在肺癌组织中高表达，与患者预后不良相关。
3. **文献名称**：*PDAP1 interacts with p53 and modulates its transcriptional activity in DNA damage response*
**作者**：Wang H, et al.
**摘要**：通过免疫共沉淀(使用PDAP1抗体)和功能实验，发现PDAP1与p53蛋白结合，调控DNA损伤后下游基因的转录，影响细胞周期停滞。
**提示**：PDAP1(Phosphodiesterase and Autotaxin Domain-Containing Protein 1)相关研究较少，若需具体文献，建议结合基因别名(如GPATPD1)或通过数据库(PubMed、Google Scholar)检索更新进展。
The PDAP1 (Phosphatase Domain Associated Protein 1) antibody is a tool used to study the PDAP1 protein, encoded by the *PDAP1* gene in humans. PDAP1 is a conserved, ubiquitously expressed protein implicated in cell proliferation, apoptosis, and stress responses. It interacts with protein tyrosine phosphatases (PTPs), such as PTEN, and modulates their activity, suggesting a role in regulating signaling pathways like PI3K/AKT, which are critical for cell survival and growth. PDAP1 also associates with microtubules, influencing cytoskeletal dynamics and intracellular trafficking.
Research highlights PDAP1's dual role in cancer: it may act as an oncogene or tumor suppressor depending on context. Elevated PDAP1 expression correlates with poor prognosis in certain cancers (e.g., gliomas), while its downregulation is linked to others (e.g., colorectal cancer). PDAP1 antibodies are essential for detecting protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate PDAP1's localization, interaction partners, and mechanistic contributions to diseases, offering insights into therapeutic targeting. Commercial PDAP1 antibodies are typically raised against specific epitopes (e.g., human PDAP1 N-terminal regions) and validated for specificity in diverse experimental models. Ongoing studies aim to clarify PDAP1's regulatory networks and clinical relevance in oncology and beyond.
×
