| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MDS023; MRPS28; MRP-S28; HDCMD11P |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MRPS35 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与MRPS35抗体相关的文献示例(注：以下为虚构内容，仅供参考格式)：
1. **文献名称**：*MRPS35 regulates mitochondrial translation and promotes hepatocellular carcinoma progression*
**作者**：Li X, et al.
**摘要**：本研究利用MRPS35抗体通过免疫印迹和免疫组化分析，发现MRPS35在肝癌组织中高表达，并证实其通过调控线粒体蛋白质合成促进肿瘤生长和转移。
2. **文献名称**：*A novel MRPS35 antibody reveals its role in mitochondrial dysfunction and neurodegenerative diseases*
**作者**：Smith J, et al.
**摘要**：开发了一种特异性MRPS35单克隆抗体，用于检测阿尔茨海默病模型中线粒体核糖体蛋白的表达变化，发现MRPS35缺失与神经元能量代谢异常相关。
3. **文献名称**：*MRPS35 interacts with apoptosis-inducing factor and modulates chemotherapy sensitivity*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀(使用MRPS35抗体)发现，MRPS35与凋亡诱导因子(AIF)相互作用，影响癌细胞对化疗药物的敏感性。
如需真实文献，建议通过PubMed或Google Scholar以“MRPS35 antibody”或“MRPS35 mitochondrial ribosome”为关键词检索。
**Background of MRPS35 Antibody**
The MRPS35 (Mitochondrial Ribosomal Protein S35) antibody is a research tool designed to detect and study the MRPS35 protein, a component of the mitochondrial ribosome's small subunit (28S). Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA, particularly those involved in oxidative phosphorylation (OXPHOS), a critical pathway for cellular energy production. MRPS35 plays a structural and functional role in maintaining ribosome integrity and facilitating translation within mitochondria.
Interest in MRPS35 stems from its potential involvement in mitochondrial dysfunction-linked diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Dysregulation of mitochondrial protein synthesis has been implicated in impaired cellular energetics and apoptosis. Researchers utilize MRPS35 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate protein expression levels, subcellular localization, and mitochondrial health in disease models.
Commercial MRPS35 antibodies are typically raised against specific epitopes, often recombinant proteins or synthetic peptides. Validation includes testing in knockdown/knockout models to confirm specificity. Recent studies also explore MRPS35's role in cancer progression, as altered mitochondrial metabolism is a hallmark of tumorigenesis. Understanding MRPS35's function through antibody-based assays may reveal therapeutic targets for mitochondrial disorders or strategies to modulate cellular energy metabolism in pathological conditions.
×
