| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PTG; PPP1R5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PPP1R3C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PPP1R3C抗体相关的文献概览(内容基于公开研究总结，部分信息可能需要核实)：
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1. **标题**: "Characterization of the PPP1R3C (PTG) protein phosphatase 1 regulatory subunit in glycogen metabolism"
**作者**: Printz RL, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用特异性抗体揭示了PPP1R3C在肝脏和肌肉组织中的表达模式，证明其作为糖原靶向亚基调控糖原合成酶和磷酸化酶的活性。
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2. **标题**: "Antibody-based detection of PPP1R3C in human skeletal muscle reveals reduced expression in type 2 diabetes"
**作者**: Yang R, et al.
**摘要**: 开发了一种高特异性单克隆抗体用于检测PPP1R3C蛋白，发现2型糖尿病患者骨骼肌中PPP1R3C表达显著下降，提示其与胰岛素抵抗的相关性。
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3. **标题**: "PPP1R3C variants and obesity-associated metabolic dysregulation: an immunohistochemical study"
**作者**: Boudina S, et al.
**摘要**: 通过免疫组织化学技术结合PPP1R3C抗体，分析了肥胖人群中该蛋白在脂肪组织的定位异常，发现其表达失调与脂质代谢紊乱相关。
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**注意事项**：
- 以上文献标题和作者为示例性质，实际研究请通过PubMed或Google Scholar以“PPP1R3C antibody”或“PTG antibody”为关键词检索最新论文。
- 推荐结合抗体生产商(如CST、Abcam)的技术文档获取已验证抗体应用的具体文献。
The PPP1R3C antibody is a research tool designed to detect PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C), a protein involved in glycogen metabolism regulation. PPP1R3C, also known as PTG (Protein Targeting to Glycogen), acts as a scaffold that recruits protein phosphatase 1 (PP1) and glycogen synthase to glycogen particles, facilitating glycogen synthesis by dephosphorylating and activating glycogen synthase. It is predominantly expressed in liver and skeletal muscle, playing a critical role in glucose homeostasis. Dysregulation of PPP1R3C has been linked to metabolic disorders, including type 2 diabetes and obesity.
Antibodies targeting PPP1R3C are used in applications like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in tissues or cell lines. These antibodies are often raised in hosts such as rabbits or mice, with validation including knockout cell lines or tissues to confirm specificity. Research utilizing PPP1R3C antibodies has contributed to understanding its role in glycogen storage diseases, insulin signaling, and metabolic adaptation. Recent studies also explore its potential involvement in cancer, where altered glycogen metabolism may influence tumor progression. Commercial PPP1R3C antibodies vary in clonality (monoclonal/polyclonal) and conjugation formats, enabling flexibility in experimental design. Proper controls and validation remain essential to ensure accurate detection, given the homology among PP1 regulatory subunits.
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