| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HSP70T; hum70t; HSP70-1L; HSP70-HOM |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSPA1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSPA1L抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*HSPA1L as a potential preeclampsia risk marker: Maternal and placental studies*
**作者**：Johnson, R. et al.
**摘要**：该研究通过Western blot和免疫组化分析，验证了一种特异性针对HSPA1L的单克隆抗体，发现其在子痫前期患者胎盘中表达显著升高，提示HSPA1L可能与胎盘应激反应相关。
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2. **文献名称**：*Characterization of a novel polyclonal antibody for HSP70 family member HSPA1L*
**作者**：Lee, S. & Martinez, A.
**摘要**：研究团队开发并验证了一种兔源多克隆抗体，通过肽段免疫法靶向HSPA1L的C端结构域。实验证实该抗体在ELISA、免疫荧光及流式细胞术中具有高特异性，且不与HSPA1A/1B交叉反应。
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3. **文献名称**：*HSPA1L genetic variants and antibody-based detection in male infertility*
**作者**：Chen, W. et al.
**摘要**：研究利用商业化HSPA1L抗体(货号ab123XX)分析精子样本，发现HSPA1L表达水平与精子活力下降相关，支持其在男性生殖细胞应激保护中的作用。
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注：以上文献信息为示例，实际引用需根据具体论文调整。建议通过PubMed或Google Scholar以关键词“HSPA1L antibody”、“HSP70-Hom antibody”检索近期或经典研究。
The HSPA1L antibody targets the heat shock protein family A (HSP70) member 1-like (HSPA1L), a constitutively expressed chaperone protein involved in cellular stress responses, protein folding, and immune modulation. HSPA1L, located on chromosome 6p21.3. shares high homology with inducible HSP70 isoforms (HSPA1A/HSPA1B) but is regulated differently, maintaining basal expression under non-stress conditions. It plays roles in maintaining proteostasis, aiding antigen presentation, and protecting cells from apoptosis during thermal or oxidative stress.
Antibodies against HSPA1L are essential tools for studying its expression, localization, and function in diseases. Researchers use them in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate HSPA1L's involvement in cancer, neurodegenerative disorders (e.g., Alzheimer’s), and inflammatory conditions. Elevated or dysregulated HSPA1L has been linked to tumor progression, chemoresistance, and neuroprotection, making it a potential therapeutic or diagnostic target.
HSPA1L polymorphisms, particularly in the promoter region, are associated with disease susceptibility, including male infertility and infection outcomes. Antibodies help validate these associations by correlating genetic variants with protein expression levels. Commercial HSPA1L antibodies are typically validated for specificity using knockout controls or siRNA, though cross-reactivity with homologous HSP70 proteins requires careful interpretation. Overall, HSPA1L antibodies advance understanding of stress response mechanisms and their pathological implications.
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