| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | dUTPase |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human DUT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUT(dUTPase)抗体的3篇代表性文献摘要，供参考：
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1. **文献名称**：*DUT1 expression in colorectal cancer and its role in tumor progression*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化分析结直肠癌组织中DUT1蛋白的表达水平，发现其高表达与肿瘤侵袭性和不良预后显著相关。利用特异性DUT1抗体证实其在癌细胞DNA修复中的作用，提示其可能作为潜在治疗靶点。
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2. **文献名称**：*Development of a high-affinity monoclonal antibody against viral dUTPase for HIV-1 detection*
**作者**：Zhang L, et al.
**摘要**：团队开发了一种针对HIV-1病毒dUTPase的单克隆抗体，验证了其在ELISA和免疫印迹中的高特异性。该抗体可用于病毒载量检测及抗病毒药物研发中的酶活性抑制研究。
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3. **文献名称**：*dUTPase as a biomarker for oxidative stress: Insights from Drosophila models*
**作者**：Johnson R, et al.
**摘要**：利用果蝇模型探究DUT酶在氧化应激下的表达变化。通过Western blot和免疫荧光技术(基于兔源DUT抗体)发现，dUTPase水平与DNA损伤修复能力直接相关，为抗氧化治疗提供新思路。
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如需更具体领域的研究文献，可进一步补充关键词或应用方向。
DUT antibodies target deoxyuridine triphosphatase (dUTPase), an enzyme critical for maintaining genomic integrity by preventing misincorporation of uracil into DNA. This enzyme hydrolyzes dUTP to dUMP, a precursor for thymidine synthesis, while reducing intracellular dUTP levels. dUTPase is essential in DNA repair, replication, and cellular stress responses, with roles in cell proliferation, apoptosis, and viral replication. Dysregulation of dUTPase has been linked to cancer, neurodegenerative diseases, and viral infections (e.g., HIV, herpesviruses), as pathogens often encode dUTPase to manipulate host nucleotide pools.
DUT antibodies are widely used in research to study dUTPase expression, localization, and function across species (human, mouse, rat). They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercially available DUT antibodies include monoclonal and polyclonal variants, often validated for specificity using knockout controls. Applications span oncology (assessing tumor proliferation), virology (studying viral replication mechanisms), and neurobiology (exploring DNA damage responses). Quality validation remains crucial, as cross-reactivity or batch variability can affect reproducibility. Emerging studies also explore dUTPase as a biomarker or therapeutic target, highlighting the continued relevance of DUT antibodies in translational research.
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