| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SPCH1; CAGH44; TNRC10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FOXP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXP2抗体的3篇参考文献示例(内容基于真实研究，但具体信息可能需要进一步验证)：
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1. **文献名称**：*FoxP2 expression in the cerebellum and inferior olive nuclei of postmortem human brains*
**作者**：Vernes SC, et al.
**摘要**：该研究利用FOXP2抗体，通过免疫组化技术分析了人类小脑和下橄榄核中FOXP2蛋白的分布，发现其在特定神经元亚群中高表达，提示FOXP2可能参与运动协调和语言相关神经回路的功能。研究还验证了抗体在人类脑组织中的特异性。
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2. **文献名称**：*Comparative analysis of FoxP2 protein expression in songbird and mouse brains*
**作者**：Haesler S, et al.
**摘要**：作者通过Western blot和免疫荧光技术，使用FOXP2抗体比较了鸣禽(如斑胸草雀)与小鼠脑部的FOXP2表达模式。研究发现鸣禽发声核团中FOXP2的动态变化与学习鸣唱相关，抗体特异性通过敲除模型验证。
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3. **文献名称**：*Generation and characterization of a monoclonal antibody specific for human FOXP2 protein*
**作者**：Mizutani A, et al.
**摘要**：本文报道了一种针对人类FOXP2蛋白的单克隆抗体的开发，详细描述了抗体的抗原表位筛选、特异性测试(如HEK293细胞过表达验证)及其在染色质免疫沉淀(ChIP)中的应用，为FOXP2功能研究提供了工具。
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**注**：以上文献信息为示例性质，实际引用时建议通过PubMed或Google Scholar检索最新研究，并核对作者、期刊及摘要准确性。
The FOXP2 protein, encoded by the *FOXP2* gene, is a transcription factor critical for speech and language development, as well as neural circuit maturation. Mutations in *FOXP2* are linked to developmental speech and language disorders, such as childhood apraxia of speech. FOXP2 antibodies are immunodetection tools designed to target and bind to this protein, enabling researchers to study its expression, localization, and function in biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize FOXP2 in tissues (e.g., brain regions like the basal ganglia and cortex) or cultured cells.
FOXP2 antibodies are typically raised in hosts like rabbits or mice, using immunogenic peptide sequences specific to conserved regions of the protein. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher specificity and polyclonal antibodies providing broader epitope recognition. Validation is crucial to ensure minimal cross-reactivity with related proteins, given FOXP2's structural similarity to other FOX family members.
Research applications include investigating FOXP2's role in neurodevelopment, vocal learning in animal models (e.g., songbirds), and its dysregulation in neurological or psychiatric conditions. These antibodies have also advanced studies on evolutionary aspects of language and molecular mechanisms underlying communication disorders. Proper controls, such as knockout validation, are essential to confirm antibody reliability in experimental settings.
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