| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | Hox-4.6, Hoxd-11 |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXD11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXD11抗体的3篇示例参考文献(内容为虚构示例，仅供格式参考)：
1. **文献名称**：*"HOXD11 Antibody Validation in Limb Development Studies"*
**作者**：Smith J. et al.
**摘要**：本研究验证了一种特异性HOXD11抗体的有效性，通过免疫组化及Western blot分析，证实其在识别小鼠胚胎肢芽发育过程中HOXD11蛋白表达的可靠性，揭示了HOXD11在肢体轴向模式形成中的关键作用。
2. **文献名称**：*"HOXD11 as a Biomarker in Metastatic Breast Cancer"*
**作者**：Zhang L. et al.
**摘要**：利用HOXD11抗体检测乳腺癌组织样本，发现HOXD11在转移性肿瘤中显著高表达，提示其可能通过调控上皮-间质转化(EMT)促进癌细胞侵袭，为预后评估提供潜在靶点。
3. **文献名称**：*"HOXD11 Antibody Application in Neural Crest Cell Research"*
**作者**：Brown K. et al.
**摘要**：通过HOXD11抗体标记技术，研究团队揭示了HOXD11在神经嵴细胞迁移和分化中的动态表达模式，证实其与颅面部发育异常的相关性，为先天性畸形机制研究提供新视角。
(注：以上文献及内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索。)
The HOXD11 antibody is a specialized tool used to detect the HOXD11 protein, a member of the homeobox (HOX) gene family critical in embryonic development and body patterning. HOX genes, organized into four clusters (A-D), encode transcription factors that regulate axial identity, limb formation, and organogenesis. HOXD11. part of the HOXD cluster on chromosome 2. plays a key role in vertebrate limb development, particularly in establishing proximal-distal patterning and digit formation. It is also implicated in urogenital system development and tissue regeneration.
HOXD11 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of the HOXD11 protein. These antibodies enable researchers to study HOXD11 expression and localization via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is validated through knockout controls or siRNA knockdown to ensure minimal cross-reactivity with other HOX proteins.
Research applications include investigating developmental disorders, congenital anomalies, and cancer, where HOXD11 dysregulation has been observed. For example, aberrant HOXD11 expression is linked to skeletal malformations, kidney defects, and certain malignancies. The antibody’s utility extends to both basic developmental biology and clinical studies, aiding in elucidating molecular mechanisms of disease. Commercial HOXD11 antibodies vary in clonality (monoclonal/polyclonal), epitope targets, and conjugates, requiring careful selection based on experimental needs. Proper validation and optimization are essential to ensure reliability in diverse biological contexts.
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