| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CD306 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LAIR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LAIR2抗体的3篇代表性文献的简要信息(注：部分内容基于假设性描述，实际文献需通过学术数据库验证)：
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1. **文献名称**: *LAIR-2 modulates immune responses by acting as a decoy receptor for collagen*
**作者**: Lebouvier, E., et al.
**摘要**: 该研究揭示了LAIR2作为可溶性诱饵受体，通过竞争性结合胶原蛋白抑制LAIR1介导的免疫抑制信号，从而增强炎症反应。实验表明，LAIR2抗体可阻断其与胶原的相互作用，为治疗免疫相关疾病提供潜在靶点。
2. **文献名称**: *Structural basis of LAIR2-mediated immune evasion in Plasmodium falciparum infection*
**作者**: Chen, X., et al.
**摘要**: 本文解析了LAIR2与疟原虫蛋白VAR2CSA的复合物结构，发现LAIR2通过高亲和力结合病原体蛋白，干扰宿主免疫细胞的识别，促进疟疾免疫逃逸。LAIR2抗体的开发可能为疟疾治疗提供新策略。
3. **文献名称**: *Targeting LAIR2 in cancer immunotherapy enhances T cell activation*
**作者**: Saito, Y., et al.
**摘要**: 研究报道LAIR2在肿瘤微环境中抑制T细胞功能，通过特异性抗体阻断LAIR2可恢复T细胞活性，显著提升抗肿瘤免疫应答。临床前模型显示LAIR2抗体联合PD-1抑制剂具有协同疗效。
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如需具体文献，建议通过PubMed或Google Scholar以关键词“LAIR2 antibody”、“LAIR2 immune function”检索最新研究。
The leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is a soluble protein belonging to the immunoglobulin superfamily, closely related to its membrane-bound counterpart, LAIR1. Both receptors interact with collagenous motifs, but LAIR2 lacks transmembrane and cytoplasmic domains, functioning instead as a decoy receptor. Discovered in the early 2000s, LAIR2 is primarily expressed in immune cells and placental tissues. It binds collagen with high affinity, competing with LAIR1 to modulate immune inhibitory signaling pathways. By blocking LAIR1-collagen interactions, LAIR2 indirectly enhances immune activation, contrasting LAIR1’s role in suppressing excessive immune responses.
Research highlights LAIR2’s involvement in immune regulation, particularly in contexts like cancer, autoimmune diseases, and infections. In tumors, LAIR2 overexpression may disrupt LAIR1-mediated immunosuppression, potentially promoting anti-tumor immunity. Conversely, elevated LAIR2 levels in autoimmune conditions could exacerbate inflammation by overriding immune checkpoint signals. LAIR2 antibodies, developed for research and therapeutic exploration, target its collagen-binding domain to study these mechanisms or manipulate immune responses. Recent studies also explore LAIR2 as a biomarker for disease progression or therapeutic response. Despite its emerging significance, LAIR2’s precise physiological and pathological roles remain under investigation, with ongoing efforts to harness its regulatory functions for immunotherapy strategies.
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