| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PDGF1; PDGF-A |
| Entrez GeneID | 5154 |
| clone | 4C1D6 |
| WB Predicted band size | 24kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human PDGFA (AA: 87-211) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是3-4条关于ITGAX抗体的参考文献示例(内容为模拟，仅供参考)：
1. **"ITGAX (CD11c) as a specific marker for dendritic cell subsets in human tissues"**
- **作者**: Schmid, M.A., Caux, C.
- **摘要**: 研究验证了ITGAX抗体在识别人类组织中树突状细胞(DCs)亚群的特异性，发现其在炎症和稳态条件下的表达差异，支持其作为DCs标记物的应用。
2. **"Targeting ITGAX in cancer-associated fibroblasts inhibits tumor growth in a murine model"**
- **作者**: Hegde, S., et al.
- **摘要**: 通过ITGAX抗体阻断肿瘤相关成纤维细胞(CAFs)中的整合素αX信号通路，显著抑制小鼠模型中肿瘤的生长和转移，提示其作为潜在治疗靶点。
3. **"ITGAX-mediated leukocyte adhesion in autoimmune lupus nephritis"**
- **作者**: Hirose, S., et al.
- **摘要**: 利用ITGAX抗体研究系统性红斑狼疮(SLE)模型，发现ITGAX通过促进白细胞粘附和浸润加剧肾脏炎症，为自身免疫疾病机制提供新见解。
4. **"Optimization of ITGAX antibody for flow cytometry: Implications for immune profiling"**
- **作者**: Hamblin, T.J., et al.
- **摘要**: 探讨不同克隆号ITGAX抗体在流式细胞术中的应用效果，优化染色条件以提高免疫细胞分型的准确性，尤其在血液样本中的实用性。
(注：以上文献为示例，实际引用时需检索真实数据库如PubMed获取准确信息。)
ITGAX, also known as integrin alpha X or CD11c, is a transmembrane protein that forms the α-subunit of the heterodimeric integrin receptor αXβ2 (CR4). It pairs with the β2 subunit (CD18) to mediate cell-cell and cell-extracellular matrix interactions, primarily in immune responses. ITGAX is highly expressed on the surface of dendritic cells, monocytes, macrophages, and a subset of activated lymphocytes, playing a critical role in leukocyte adhesion, migration, and phagocytosis. Its ligands include ICAM-1. fibrinogen, and iC3b, facilitating pathogen recognition, immune surveillance, and inflammatory processes.
Antibodies targeting ITGAX (CD11c) are widely used in research to identify and isolate dendritic cells and myeloid cell populations in tissues or circulation. They serve as key tools in flow cytometry, immunohistochemistry, and functional studies to dissect immune cell behavior in homeostasis and disease. In pathological contexts, ITGAX expression is linked to chronic inflammation, autoimmune disorders (e.g., lupus, multiple sclerosis), and cancer. For example, tumor-associated macrophages expressing CD11c may correlate with tumor progression or immune modulation.
Recent studies explore ITGAX antibodies for therapeutic applications, such as blocking leukocyte infiltration in inflammatory diseases or enhancing antigen presentation in immunotherapy. Their specificity makes them valuable for both diagnostic and experimental investigations into immune regulation and targeted therapies.
×
