| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CSF; GMCSF |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CSF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于AKAP8抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
1. **文献名称**：*AKAP8 interacts with estrogen receptor alpha and modulates its transcriptional activity in breast cancer cells*
**作者**：Smith J, et al. (2021)
**摘要**：本研究利用AKAP8特异性抗体，通过免疫共沉淀技术证实AKAP8与雌激素受体α(ERα)在乳腺癌细胞中存在物理互作，并发现其通过调控染色质重塑影响ERα靶基因表达。
2. **文献名称**：*AKAP8 as a novel prognostic biomarker in hepatocellular carcinoma: Insights from immunohistochemical analysis*
**作者**：Wang L, et al. (2019)
**摘要**：通过AKAP8抗体进行组织芯片免疫组化分析，揭示AKAP8在肝癌组织中显著高表达，其表达水平与患者总生存期负相关，提示其作为潜在预后标志物的价值。
3. **文献名称**：*AKAP8 mediates DNA damage response through anchoring PKA to nuclear foci*
**作者**：Chen R, et al. (2020)
**摘要**：利用AKAP8抗体进行亚细胞定位研究，发现其在DNA损伤条件下募集PKA至核内损伤位点，通过磷酸化H2AX调控DNA修复过程，阐明了AKAP8在基因组稳定性维持中的新机制。
注：以上文献信息为基于真实研究方向的模拟数据，实际引用时请以权威数据库收录文献为准。
The A-kinase anchoring protein 8 (AKAP8) is a member of the AKAP family, which compartmentalizes protein kinase A (PKA) and other signaling molecules to regulate localized cellular processes. AKAP8. also known as AKAP95. is primarily nuclear and plays roles in transcriptional regulation, RNA processing, and chromatin remodeling by tethering PKA and other partners (e.g., protein phosphatases, RNA-binding proteins) to specific subcellular sites. It is implicated in cell cycle progression, DNA repair, and maintaining genomic stability.
AKAP8 antibodies are essential tools for studying its expression, localization, and interactions in these pathways. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore AKAP8's functional dynamics in health and disease. Research links AKAP8 dysregulation to cancers, neurodevelopmental disorders, and cardiovascular diseases, making its antibodies valuable for mechanistic and diagnostic studies.
Structurally, AKAP8 contains conserved domains for PKA binding and nucleic acid interactions. Alternative splicing generates isoforms (e.g., AKAP8 and AKAP8B), and some antibodies distinguish these variants by targeting unique epitopes. Validation of AKAP8 antibodies ensures specificity, as cross-reactivity with homologous proteins (e.g., AKAP8L) can occur. Ongoing research aims to clarify its tissue-specific roles and therapeutic potential, underscoring the importance of reliable AKAP8 antibodies in biomedical research.
×
