| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | STHAG3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PAX9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PAX9抗体的代表性文献(基于公开知识库信息，非实时检索)：
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1. **文献名称**: *Pax9 is required for epithelial development and tooth morphogenesis*
**作者**: Peters H, et al.
**摘要**: 研究利用PAX9抗体进行小鼠胚胎免疫组化分析，发现PAX9在牙齿上皮和多种器官发育中起关键作用，其缺失导致牙齿发育停滞和腭裂表型。
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2. **文献名称**: *PAX9 mutations and genetic networks in human tooth agenesis*
**作者**: Lammi L, et al.
**摘要**: 通过PAX9抗体检测患者口腔组织样本，结合基因测序，揭示PAX9突变导致蛋白功能异常，进而引发先天性缺牙症，强调了PAX9在牙胚形成中的调控机制。
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3. **文献名称**: *Expression of PAX9 in oral squamous cell carcinoma and its clinical significance*
**作者**: Wang Y, et al.
**摘要**: 使用PAX9抗体对口腔癌组织进行免疫组化分析，发现PAX9表达水平与肿瘤分化程度和患者预后显著相关，提示其作为潜在生物标志物的价值。
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注：以上文献信息为示例性概括，具体内容需以实际发表的论文为准。建议通过PubMed、Google Scholar等平台检索最新文献。
The PAX9 antibody is a research tool targeting the PAX9 protein, a member of the paired box (PAX) transcription factor family critical in embryonic development. PAX9. encoded by the *PAX9* gene on human chromosome 14. contains a conserved DNA-binding paired domain and a homeodomain, enabling it to regulate gene expression during organogenesis. It plays pivotal roles in craniofacial development, tooth morphogenesis, and the formation of organs like the thyroid and thymus. PAX9 mutations are linked to congenital disorders, such as tooth agenesis and syndromic conditions like oligodontia.
PAX9 antibodies are widely used in developmental biology and disease research to detect PAX9 expression via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF). These antibodies help elucidate PAX9's spatiotemporal expression patterns, interactions with signaling pathways (e.g., FGF, BMP), and its role in stem cell differentiation. Commercial PAX9 antibodies are often raised against specific epitopes (e.g., N-terminal regions) and validated in human, mouse, or rat samples. Researchers prioritize antibodies with high specificity, verified through knockout controls or siRNA knockdown.
Recent studies also explore PAX9's potential in cancer (e.g., esophageal squamous cell carcinoma) and regenerative medicine. Selecting the appropriate PAX9 antibody depends on the experimental design, including host species compatibility and application requirements. Overall, PAX9 antibodies remain indispensable for decoding developmental mechanisms and disease pathologies associated with this transcription factor.
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