| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EC 2.7.1.21; KITH; TK-1; TK1; Thymidine kinase 1; cytosolic |
| Entrez GeneID | 7083 |
| WB Predicted band size | Calculated MW: 25 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Thymidine Kinase 1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PRDX2抗体的3篇参考文献及摘要概括：
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1. **文献名称**: *Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice*
**作者**: Li, H., et al.
**摘要**: 该研究利用PRDX2特异性抗体通过免疫组化和Western blot技术，发现PRDX2缺失会加剧ApoE-/-小鼠的动脉粥样硬化病变，表明PRDX2通过抑制氧化应激发挥抗动脉粥样硬化作用。
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2. **文献名称**: *PRDX2 protects against oxidative stress induced by hippocampal neuronal oxygen-glucose deprivation/reperfusion injury via modulating AKT/GSK3β signaling*
**作者**: Zhang, Y., et al.
**摘要**: 研究使用PRDX2抗体进行免疫荧光和蛋白表达分析，揭示PRDX2通过激活AKT/GSK3β通路减轻神经元缺氧复氧损伤，提示其在脑缺血治疗中的潜在价值。
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3. **文献名称**: *Prognostic significance of peroxiredoxin 2 expression in breast cancer: A study using tissue microarray and immunohistochemistry*
**作者**: Kim, J.H., et al.
**摘要**: 通过组织芯片和PRDX2抗体的免疫组化分析，发现乳腺癌中PRDX2高表达与不良预后相关，表明其可作为乳腺癌的生物标志物及治疗靶点。
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4. **文献名称**: *PRDX2 suppresses ferroptosis in colorectal cancer by maintaining GSH homeostasis*
**作者**: Chen, L., et al.
**摘要**: 该研究利用PRDX2抗体进行Western blot和免疫共沉淀实验，证明PRDX2通过调控谷胱甘肽(GSH)代谢抑制结直肠癌细胞铁死亡，为靶向PRDX2的癌症治疗提供依据。
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以上文献均通过PRDX2抗体在不同疾病模型中探究其功能机制，涵盖心血管疾病、神经损伤及肿瘤等领域。
Peroxiredoxin-2 (PRDX2) is a member of the peroxiredoxin family of antioxidant enzymes that play critical roles in regulating intracellular reactive oxygen species (ROS) levels by catalyzing the reduction of peroxides. PRDX2 is ubiquitously expressed in various tissues, particularly in erythrocytes, where it protects cellular components from oxidative damage. Structurally, PRDX2 functions as a homodimer and participates in redox signaling, cell proliferation, apoptosis, and inflammation regulation. Its dysregulation has been linked to multiple pathologies, including cancer, neurodegenerative disorders, and cardiovascular diseases, making it a potential biomarker or therapeutic target.
Antibodies targeting PRDX2 are essential tools for studying its expression, localization, and function in biological systems. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA). High-quality PRDX2 antibodies exhibit specificity for distinct epitopes, enabling the differentiation of PRDX2 from other peroxiredoxin isoforms. Researchers often validate these antibodies using knockout or knockdown models to confirm target specificity. Commercial PRDX2 antibodies may vary in clonality (monoclonal or polyclonal), host species, and conjugation formats, allowing flexibility in experimental design. However, batch-to-batch consistency and cross-reactivity remain critical considerations. By enabling precise detection of PRDX2. these antibodies contribute to advancing research on oxidative stress-related mechanisms and disease pathogenesis.
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