| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | RFWD1, RNF119 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRAF7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRAF7抗体的3篇代表性文献的简要概括(文献标题、作者及摘要内容均为示例，实际文献可能需要根据具体数据库检索确认)：
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1. **文献名称**：*TRAF7 mutations in craniopharyngioma and antibody validation*
**作者**：E.G. Ortiz-Sánchez, et al.
**摘要**：本研究通过免疫组化和Western blot验证了TRAF7抗体在颅咽管瘤组织中的特异性，发现TRAF7突变导致其与β-catenin通路的异常互作，抗体可用于突变蛋白的病理检测。
2. **文献名称**：*TRAF7 functions as a tumor suppressor via regulating NF-κB signaling*
**作者**：M. Sánchez-Tilló, et al.
**摘要**：利用TRAF7抗体进行蛋白质互作分析，揭示TRAF7作为泛素连接酶通过降解特定激酶抑制NF-κB通路，抗体在体外实验中有效识别内源性TRAF7蛋白。
3. **文献名称**：*TRAF7 antibody application in cardiac fibrosis research*
**作者**：H. Chen, et al.
**摘要**：研究报道TRAF7在心脏纤维化中的表达上调，通过免疫沉淀和抗体阻断实验证明其通过TAK1调控心肌细胞凋亡，相关抗体为疾病标志物研究提供工具。
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**注**：以上文献为示例，实际文献需通过PubMed、Google Scholar等平台以“TRAF7 antibody”或“TRAF7 function”为关键词检索。部分真实文献可能侧重抗体开发(如抗体验证方法)或疾病机制研究(如癌症、罕见病)。
**Background of TRAF7 Antibody**
TRAF7 (TNF receptor-associated factor 7) is a member of the TRAF protein family, which plays roles in intracellular signaling pathways, including NF-κB and MAPK regulation. Unlike other TRAF proteins, TRAF7 uniquely combines a RING domain with WD40 repeats, functioning as an E3 ubiquitin ligase and scaffolding protein. It is implicated in diverse cellular processes, such as apoptosis, immune response, and stress signaling. TRAF7 mutations or dysregulation are linked to cancers (e.g., meningiomas, gliomas) and rare genetic disorders like cardiofaciocutaneous syndrome.
TRAF7 antibodies are essential tools for detecting TRAF7 expression in research, enabling studies on its molecular mechanisms and disease associations. These antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein localization, expression levels, and interactions. Commercially available TRAF7 antibodies are typically validated for specificity against human or murine isoforms. Recent studies highlight TRAF7's role in tumorigenesis and its potential as a therapeutic target, driving demand for reliable antibodies to explore its functional pathways and clinical relevance. Understanding TRAF7's signaling dynamics through antibody-based assays contributes to insights into cancer biology and rare developmental disorders.
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