| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | THC2; bA145E8.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ANKRD26 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ANKRD26抗体相关的文献摘要概览：
1. **"ANKRD26-related thrombocytopenia and myeloid malignancies"**
- 作者：Noris P. et al. (Blood, 2013)
- 摘要：研究揭示了ANKRD26基因突变导致血小板减少症的分子机制，并发现其与白血病转化的相关性。文中使用ANKRD26抗体验证了突变体蛋白在患者血小板中的异常表达。
2. **"Proteomic characterization of ANKRD26 in acute myeloid leukemia"**
- 作者：Smith A. et al. (Leukemia Research, 2018)
- 摘要：通过ANKRD26特异性抗体进行蛋白质组学分析，发现其在AML细胞中高表达，并参与调控JAK-STAT信号通路，提示其作为白血病治疗靶点的潜力。
3. **"Development of a monoclonal antibody against ANKRD26 for cancer diagnostics"**
- 作者：Chen L. et al. (Scientific Reports, 2020)
- 摘要：报道了一种新型ANKRD26单克隆抗体的开发，验证其在多种癌症组织中的特异性识别能力，并探索其作为肿瘤标志物的临床应用价值。
注：以上为基于领域知识的文献模拟概括，实际文献需通过PubMed或Google Scholar检索确认。
The ANKRD26 antibody targets the protein encoded by the *ANKRD26* gene, which is located on human chromosome 10p12.1. This gene encodes a large, multidomain protein containing an N-terminal ankyrin repeat domain, a central coiled-coil region, and a C-terminal proline-rich domain. ANKRD26 is implicated in various cellular processes, including signal transduction, cytoskeletal organization, and transcriptional regulation. Dysregulation of ANKRD26 has been linked to inherited thrombocytopenia (ANKRD26-related thrombocytopenia) caused by mutations in the 5' untranslated region of the gene, leading to abnormal platelet production and an increased risk of hematologic malignancies.
ANKRD26 antibodies are primarily used in research to study the protein’s expression, localization, and function in both normal and pathological contexts. In diagnostic settings, these antibodies may aid in identifying genetic disorders associated with ANKRD26 mutations. Studies also suggest a role for ANKRD26 in cancer biology, with altered expression observed in leukemia, breast cancer, and other solid tumors. Commercially available ANKRD26 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. However, researchers must verify antibody specificity due to potential cross-reactivity with other ankyrin repeat-containing proteins. Ongoing research aims to clarify ANKRD26’s molecular mechanisms and therapeutic potential in hematologic and oncologic diseases.
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