| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MAPK11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAPK11抗体的3篇代表性文献，按文献名称、作者和摘要内容概括整理：
1. **"p38 MAPK isoforms: A comparative study of cellular functions and signaling specificity"**
*作者：Cuadrado A, Nebreda AR*
**摘要**：比较了p38 MAPK家族不同亚型(包括MAPK11/p38β)的生物学功能，利用特异性抗体验证了其在炎症反应和细胞应激中的差异激活机制。
2. **"MAPK11 regulates osteoclast differentiation and bone homeostasis via modulating RANKL signaling"**
*作者：Li J, et al.*
**摘要**：通过Western blot和免疫荧光实验(使用MAPK11特异性抗体)，揭示MAPK11在破骨细胞分化中的关键作用及其通过RANKL信号通路调控骨代谢的机制。
3. **"Selective inhibition of MAPK11 enhances antitumor immunity by modulating the tumor microenvironment"**
*作者：Wang Y, et al.*
**摘要**：利用MAPK11抗体检测肿瘤组织中MAPK11的表达水平，发现其特异性抑制剂可通过调节免疫细胞浸润抑制肿瘤生长，为癌症免疫治疗提供新靶点。
以上文献均通过MAPK11抗体验证了该蛋白在不同生理病理过程中的表达与功能，涵盖炎症、骨代谢及肿瘤免疫等领域。如需具体DOI或期刊信息，可进一步补充。
**Background of MAPK11 Antibody**
The MAPK11 (mitogen-activated protein kinase 11) antibody is a key tool for studying the p38 mitogen-activated protein kinase (MAPK) family, which regulates cellular responses to stress, inflammation, and apoptosis. MAPK11. also known as p38β, is one of four p38 isoforms (p38α, β, γ, δ) and shares structural homology with p38α. It is activated by upstream kinases (MKK3/6) in response to cytokines, environmental stressors, or growth factors, leading to phosphorylation of downstream targets involved in cell differentiation, survival, and cytokine production.
MAPK11-specific antibodies are designed to detect endogenous levels of the protein, often targeting unique epitopes in its N- or C-terminal regions. These antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence to explore MAPK11 expression, activation (via phospho-specific antibodies), and localization in tissues or cell lines. Research using MAPK11 antibodies has linked its dysregulation to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions, highlighting its role as a potential therapeutic target.
Specificity is critical, as cross-reactivity with other p38 isoforms can occur. High-quality antibodies are typically verified using knockout controls or siRNA-mediated silencing. Their use advances understanding of MAPK11's distinct functions in signaling pathways, complementing studies on overlapping or isoform-specific mechanisms in health and disease.
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