| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MEKK2; MEKK2B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MAP3K2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MAP3K2抗体的相关文献摘要(示例为模拟生成，非真实文献)：
1. **文献名称**：*MAP3K2 regulates RAS-driven lung cancer growth through kinase-dependent and -independent pathways*
**作者**：Zhang Y, et al.
**摘要**：研究利用MAP3K2特异性抗体进行免疫共沉淀实验，揭示MAP3K2通过磷酸化下游靶点及支架蛋白相互作用，促进KRAS突变肺癌细胞的增殖和转移。
2. **文献名称**：*Antibody-based profiling of MAP3K2 in hepatocellular carcinoma reveals its prognostic significance*
**作者**：Li H, Wang X.
**摘要**：通过Western blot和免疫组化验证商业化MAP3K2抗体的特异性，发现MAP3K2在肝癌组织中高表达，且与患者生存率负相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*MAP3K2 controls T cell differentiation via JNK/c-Jun signaling*
**作者**：Smith J, et al.
**摘要**：研究使用CRISPR敲除结合MAP3K2抗体阻断实验，证明MAP3K2通过调控JNK通路影响Th17细胞分化，为自身免疫疾病机制提供新见解。
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注：以上内容为示例，实际文献需通过PubMed/Google Scholar检索关键词“MAP3K2 antibody”或“MAP3K2 function”获取。真实文献可能侧重抗体开发(如《*Monoclonal antibody generation against human MAP3K2*》)或疾病机制研究。
The MAP3K2 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase kinase 2 (MAP3K2), a serine/threonine kinase within the MAPK signaling cascade. MAP3K2. also known as MEKK2. plays a pivotal role in regulating cellular responses such as proliferation, differentiation, apoptosis, and stress signaling. It activates downstream MAPK pathways (e.g., JNK, ERK, p38) by phosphorylating MAP2Ks, often in response to extracellular stimuli like cytokines, growth factors, or environmental stress. Dysregulation of MAP3K2 is implicated in cancer, inflammatory diseases, and developmental disorders, making it a therapeutic target of interest.
Antibodies targeting MAP3K2 enable researchers to detect and quantify its expression, phosphorylation status, and interactions in various experimental models. These antibodies are widely used in techniques including Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. Specific isoforms or phosphorylated forms of MAP3K2 can be identified using phosphorylation-specific antibodies, aiding in the study of pathway activation dynamics. Additionally, MAP3K2 inhibitors are being explored in preclinical studies, and corresponding antibodies help assess drug efficacy by monitoring pathway inhibition. Research has highlighted its role in RAS-driven tumors, immune cell signaling, and epithelial-mesenchymal transition (EMT), underscoring its relevance in both basic and translational biomedical research.
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